Sort   by:  
 Page size 
ProteomicsThe CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
The cell-autonomous balance of immune-inhibitory and -stimulatory signals is a critical process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse models, and single cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, we find that int...
ORGANISM(S): Homo sapiens (Human) 
2023-07-06 | PXD039710 | Pride
Human Cd58 Melanoma 
GenomicsGenome-wide CRISPR screen to identify CD58 regulators
Genome-wide CRISPR screen to identify CD58 regulators
PRJNA934388 | ENA
GenomicsCD58 loss in tumor cells confers functional impairment of CAR T cells
CD58 loss in tumor cells confers functional impairment of CAR T cells
PRJNA833876 | ENA
UnknownCD58 Immunobiology at a Glance.
Not available
S-EPMC8218816 | biostudies-literature
OtherGenome-wide CRISPR screen to identify CD58 regulators
The cell autonomous balance of immune-inhibitory and -stimulatory signals is a critical yet poorly understood process in cancer immune evasion. Using patient-derived co-culture models and humanized mouse models, we show that an intact CD58:CD2 interaction is necessary for anti-tumor immunity. Defect...
ORGANISM(S): Homo sapiens 
2023-05-09 | GSE225235 | GEO
UnknownCD58 defines regulatory macrophages within the tumor microenvironment.
Not available
S-EPMC11335740 | biostudies-literature
UnknownThe role of the CD58 locus in multiple sclerosis.
Not available
S-EPMC2664005 | biostudies-literature
TranscriptomicsCD58 loss in tumor cells confers functional impairment of CAR T cells
Chimeric antigen receptor (CAR) T-cell therapy has achieved significant success in treating a variety of hematologic malignancies, but resistance to this treatment in some patients limited its wider application. Using an unbiased genome-wide CRISPR/Cas9 screening, we identified and validated loss of...
ORGANISM(S): Homo sapiens 
2022-05-03 | GSE201970 | GEO
UnknownForced detachment of the CD2-CD58 complex.
Not available
S-EPMC1302789 | biostudies-literature
UnknownPAX5 epigenetically orchestrates CD58 transcription and modulates blinatumomab response in acute lymphoblastic leukemia.
Not available
S-EPMC9750140 | biostudies-literature
Sort   by:  
 Page size