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ProteomicsNudt21 controls cell fate by connecting alternative polyadenylation to chromatin signaling
Cell fate transitions involve rapid changes of gene expression patterns and global chromatin remodeling, yet the underlying regulatory pathways remain incompletely understood. Here, we used transcription-factor induced reprogramming of somatic cells into pluripotent cells to screen for novel regulat...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-08 | PXD008078 | Pride
Nudt21 tmt 
TranscriptomicsmRNA profiling of genetically matched ESCs and iPSCs
Induced pluripotent stem cells (iPSCs) can be generated by enforced expression of defined transcription factors in somatic cells. It remains controversial whether iPSCs are equivalent to blastocyst-derived embryonic stem cells (ESCs). Using genetically matched cells, we found that the overall mRNA ...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-20572 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of iPSCs and derivative NT-ESCs
Pluripotent cells can be derived from somatic cells by either overexpression of defined transcription factors (resulting in induced pluripotent stem cells (iPSCs)) or by nuclear transfer or cloning (resulting in NT-ESCs). To determine whether cloning further reprograms iPSCs, we used iPSCs as donor ...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20575 | biostudies-arrayexpress
TranscriptomicsExpressoin data from iPSC with different cell of origin
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. We use expresson profiling to determine differn...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-22043 | biostudies-arrayexpress
TranscriptomicsNanog is Dispensable for the Generation of Induced Pluripotent Stem Cells
Cellular reprogramming from somatic cells to induced pluripotent stem cells (iPSCs) can be achieved through forced expression of the transcription factors Oct4, Klf4, Sox2 and c-Myc (OKSM). These factors, in combination with environmental cues, induce a stable intrinsic pluripotency network that con...
ORGANISM(S): Mus musculus 
2014-01-28 | E-GEOD-53832 | biostudies-arrayexpress
TranscriptomicsCell of origin influences molecular and functional properties of murine induced pluripotent stem cells
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPSCs generated from different cell types are molecularly and functionally similar. Here, we show that iPSCs obtained from fibrobla...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22827 | biostudies-arrayexpress
TranscriptomicsDefining a molecular roadmap of cellular reprogramming into iPS Cells [DNA methylation]
Factor-induced reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is inefficient, complicating mechanistic studies. Here, we examined defined intermediate cell populations poised to becoming iPSCs by genome-wide analyses. We show that induced pluripotency elicits two transcri...
ORGANISM(S): Mus musculus 
2013-03-18 | E-GEOD-45248 | biostudies-arrayexpress
TranscriptomicsCNV analysis of iPS cell lines and H2A.X knockout ES cell
It is well-known that embryonic stem cells (ESC) are much more sensitive to replication-induced stress than differentiated cells but the underpinning mechanisms are largely unknown. H2A.X, a minor variant of H2A, constitutes only 1-10% of the mammalian genome. H2A.X plays a well-known for role in t...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42266 | biostudies-arrayexpress
GenomicsThe histone chaperone CAF-1 safeguards somatic cell identity during transcription factor-induced reprogramming (sequencing)
During development, specialized cell lineages are generated through the establishment of cell type-specific transcriptional patterns and epigenetic programs. However, the precise mechanisms and regulators that maintain these specialized cell states remain largely elusive. To identify molecules that ...
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-72744 | biostudies-arrayexpress
TranscriptomicsThe histone chaperone CAF-1 safeguards somatic cell identity during transcription factor-induced reprogramming
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-12-10 | E-GEOD-66534 | biostudies-arrayexpress
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