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UnknownNovel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies.
Not available
S-EPMC5914326 | biostudies-literature
UnknownEngraftment of retrovirally transduced Bet v 1-GFP expressing bone marrow cells leads to allergen-specific tolerance.
Not available
S-EPMC6624140 | biostudies-literature
ProteomicsPhosphoproteomics of human MV4-11 AML cells treated with Gilteritinib
Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25% of acute myeloid leukemia (AML) patients and lead to constitutive activation of FLT3, driving leukemia cell survival and proliferation. Quizartinib, crenolanib and gilteritinib are second-generation FLT3 inhibitors ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD023123 | Pride
Human Lc-msms Flt3 Aml 
ProteomicsPhosphoproteomics of primary human FLT3-ITD+ AML cells treated with gilteritinib
Primary human AML cells (newly diagnosed, prior to treatment initation) were obtained from donor after consent and AML blasts were isolated by standard Ficoll centrifugation. AML blasts were treated with FLT3 inhibitor gilteritinib (or DMSO vehicle control) at 10 nM concentration for 6 h, followed b...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD034080 | Pride
Aml Gilteritinib Flt3 
ProteomicsTranslatome proteomics of human AML cells treated with FLT3 inhibitors quizartinib, crenolanib, gilteritinib
Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25% of acute myeloid leukemia (AML) patients and lead to constitutive activation of FLT3, driving leukemia cell survival and proliferation. Quizartinib, crenolanib and gilteritinib are second-generation FLT3 inhibitors ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD023125 | Pride
Human Lc-msms Flt3 Aml 
ProteomicsTranslatome proteomics of primary human FLT3-ITD+ AML cells treated with FLT3 inhibitors quizartinib, crenolanib, gilteritinib
Primary human AML cells (newly diagnosed, prior to treatment initation) was obtained from donor after consent and AML blasts were isolated by standard Ficoll centrifugation. Cells were treated ex vivo with DMSO vehicle control or 10 nM FLT3 inhibitors quizartinib, crenolanib, gilteritinib for 6 hour...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD034081 | Pride
Aml Gilteritinib Flt3 Translatome Quizartinib Crenolanib 
ProteomicsTMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer
This dataset contains an evaluation of TMT-based multiplexed proteomics on the Orbitrap Astral mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-12-17 | MSV000096674 | MassIVE
UnknownAβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Not available
S-EPMC6527709 | biostudies-literature
UnknownFactors associated with the opposition to COVID-19 vaccination certificates: A multi-country observational study from Asia.
Not available
S-EPMC9113761 | biostudies-literature
ProteomicsNarrow-window DIA: Ultra-fast quantitative analysis of comprehensive proteomes with high sequencing depth. Evaluation of window width and injection time.
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes in a fast and reproducible manner. Here, we present an ultra-fast scanning data-independent acquisition (DIA) strategy consisting on 2-Th precursor isolation windows, dissolving the differences between data-dependen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095977 | MassIVE
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