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TranscriptomicsComparative transcriptional profiling of the lung discriminates S. pneumoniae and Influenza A Virus infections
Peumonia is the most common cause of death due to infectious diseases in the western hemisphere. The molecular events associated with pulmonary infections caused by Streptococcus pneumoniae and Influenza A virus are incompletely understood. Pathophysiological and protective processes are initiated b...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-5289 | biostudies-arrayexpress
TranscriptomicsRNA-seq of coding RNA of Streptococcus pneumoniae D39 after FCS addition
Streptococcus pneumoniae (S.p.) is the most common causative agent of community-acquired pneumonia worldwide. A key pathogenic mechanism that exacerbates severity of disease is the disruption of the alveolo-capillary barrier. However, the specific virulence mechanisms responsible for this in the hum...
ORGANISM(S): Streptococcus pneumoniae 
2023-11-30 | E-MTAB-13533 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of hiPSC derived alveolar-like lung organoids upon H3N2 infection
hiPSC from 2 different donors were differentiated into alveolar-like organoids (iPSC-aLOs) as previously described (DOI: 10.1038/s41596-019-0220-0). iPSC-aLOs were either kept in \"dome\" culture embedded in extracellular matrix or inverted in apical-out conformation to allow influenza H3N2 infectio...
ORGANISM(S): Homo sapiens 
2025-11-27 | E-MTAB-15980 | biostudies-arrayexpress
TranscriptomicsCell-specific Interleukin-15 and Interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia
IL-15 has critical impact on the homeostasis and activation of NK, NKT, gdT and CD8+T cells, and contributes to antimicrobial defenses particularly at mucosal sites. The respiratory tract also comprises a large mucosal surface and harbors significant amounts of lymphocytes, but the expression patter...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-3631 | biostudies-arrayexpress
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
TranscriptomicsEpigenomic characterization of patient-derived lung tumoroids using DNA methylation profiling
DNA methylation analysis of patient-derived lung tumoroids and matched healthy organoids demonstrates preservation of tumor-specific epigenomic identity during long-term culture. Tumoroids maintain the methylation landscape of their parental tumors, with samples from the same patient clustering toge...
ORGANISM(S): Homo sapiens 
2025-12-29 | E-MTAB-16020 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-03-08-2020-18:14:14:560-2122 - samples
To investigate the immune response and mechanisms associated with severe COVID-19, we performed single-cell RNA-seq on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from 5 healthy controls. We identified airway epithelial ce...
EGAD00001006339 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsSingle-cell analysis of airway samples identifies immune cell activation correlating with COVID-19 disease severity
To investigate the immune response and mechanisms associated with severe COVID-19, we performed single-cell RNA-seq on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from 5 healthy controls. We identified airway epithelial ce...
EGAS00001004481 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
GenomicsBIH COVID-19 airway single-cell data access committee.
Data Access Committee EGAC00001001627
EGAC00001001627 | EGA
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