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UnknownAssessment of Child Lead Exposure in a Philadelphia Community, 2014.
Not available
S-EPMC6916666 | biostudies-literature
ProteomicseIF4A1 unwinding activity is RNA sequence-specifically deployed through eIF4A1-multimerisation to facilitate translation of mRNAs with local repressive RNA structure
Oncogenic translational programmes are an emerging hallmark of cancer and often driven by dysregulation of signaling pathways including KRAS and mTORC that converge on the eukaryotic translation initiation (eIF) 4F complex. Altered eIF4F activity promotes translation of oncogene mRNAs that typically...
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD034343 | Pride
Proteomics Tmt Eif4a1 Pulse silac 
ProteomicsLuminescent sensing of conformational integrin activation in living cells
Integrins are the major receptors for secreted extracellular matrix, playing crucial roles in several physiological and pathological contexts, such as angiogenesis and cancer. Regulation of the transition between inactive and active conformation is key for integrins to fulfill their functions, and p...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051442 | Pride
Tmt Human Vegfb Proteomics 
ProteomicseIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5’UTR.
Regulation of the mRNA life-cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understood. Here we show eIF4A2 is a major effector of the repressiv...
ORGANISM(S): Homo sapiens (Human) 
2019-10-08 | PXD014764 | Pride
Translation control Dead-box helicase Pulsed silac 
ProteomicsOmentum-derived matrix enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment
High-grade serous (HGS) ovarian cancer is the most lethal gynaecological disease in the world and metastases is a major cause. The omentum is the preferential metastatic site in HGS ovarian cancer patients and in vitro models that recapitulate the original environment of this organ at cellular and m...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-28 | PXD045024 | Pride
Extracellular matrix  ovarian cancer  caf  matrisome  omentum 
ProteomicsOmentum gel enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment
High-grade serous (HGS) ovarian cancer is the most common and aggressive ovarian cancer type, and the most lethal gynaecological disease 1,2. The major cause is its highly metastatic nature and the limited availability of effective therapies to oppose it. The omentum is a highly vascularised viscera...
ORGANISM(S): Homo sapiens (Human) 
2023-11-28 | PXD042317 | Pride
Extracellular matrix  ovarian cancer  caf  matrisome  omentum 
ProteomicsOmentum gel enables the study of metastatic ovarian cancer and stromal cell functions in a physiologically relevant environment
High-grade serous (HGS) ovarian cancer is the most common and aggressive ovarian cancer type, and the most lethal gynaecological disease 1,2. The major cause is its highly metastatic nature and the limited availability of effective therapies to oppose it. The omentum is a highly vascularised viscera...
ORGANISM(S): Homo sapiens (Human) 
2023-11-28 | PXD042320 | Pride
Extracellular matrix  ovarian cancer  caf  matrisome  omentum 
ProteomicsPlant SILAC: Stable-Isotope Labelling with Amino Acids of Arabidopsis Seedlings for Quantitative Proteomics.
Stable Isotope Labelling by Amino acids in Cell culture (SILAC) is a powerful technique for comparative quantitative proteomics, which has recently been applied to a number of different eukaryotic organisms. Inefficient incorporation of labelled amino acids in cell cultures of Arabidopsis thaliana h...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2016-08-15 | MSV000080043 | MassIVE
UnknownA Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect.
Not available
S-EPMC12422598 | biostudies-literature
UnknownNeuromodulation for Children With Hemiparesis and Perinatal Stroke: A Randomized Clinical Trial.
Not available
S-EPMC11791770 | biostudies-literature
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