Sort   by:  
 Page size 
TranscriptomicsAging Experiment
Lifelong murine gene expression profiles in relation to chronological and biological aging in multiple organs Five tissues: Kidney, Liver, Lung, Spleen, Brain. Six timepoints: 13wks, 26 wks, 52wks, 78wks, 104wks, 130wks. One Genotype: C57Bl/6, 3 replicates
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-34378 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Ercc1-/- mice and wild type littermates to investigate features of premature aging
To investigate the cause of the premature aging features in the Ercc1-/- mouse, we compared the entire transcriptome of the Ercc1-/- mouse liver to that of wildtype littermates at the age of 15 days, when the Ercc1-/- mice reached their maximal weight and had symptoms of progeria, yet overall pathol...
ORGANISM(S): Mus musculus 
2006-12-21 | E-MEXP-834 | biostudies-arrayexpress
UnknownThe progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.
Not available
S-EPMC3989187 | biostudies-literature
TranscriptomicsTranscription profiling of liver, lung, spleen and kidney from young (13 week) and aged (130 week) wild type mice
We compared the complete mouse liver, spleen, lung and kidney transcriptome of adult 13- and 130-wk old wt C57Bl/6J mice (n=3) to develop gene sets for young adult and aged wt mice, respectively
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1504 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type or Ercc1 mutant mice
The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To ...
ORGANISM(S): Mus musculus 
2008-06-01 | E-MEXP-1503 | biostudies-arrayexpress
UnknownDisruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
Not available
S-EPMC85844 | biostudies-literature
UnknownA link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells.
Not available
S-EPMC3539748 | biostudies-literature
UnknownDNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.
Not available
S-EPMC1472908 | biostudies-literature
UnknownDNA damage in normally and prematurely aged mice.
Not available
S-EPMC3655155 | biostudies-literature
UnknownLife spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.
Not available
S-EPMC3772962 | biostudies-literature
Sort   by:  
 Page size