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TranscriptomicsThe Nucleosome Landscape of P. falciparum Reveals Chromatin Architecture and Dynamics of Regulatory Sequences
In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-related processes. For P. falciparum, the causative agent of human malaria, the nucleosome landscape of the extremely AT-rich intergenic regulatory regions is largely unexplored. With the aid of a highly controlled MN...
ORGANISM(S): Plasmodium falciparum 
2015-11-25 | E-GEOD-66185 | biostudies-arrayexpress
GenomicsHistone variant, H2B.Z demarcates the AT-rich promoter regions of the Plasmodium falciparum genome
Histone variants are key components of the epigenetic code and evolved to perform specific functions in transcriptional regulation, DNA repair, chromosome segregation and other fundamental processes. H2B.Z is a rare, apicomplexan-specific variant of histone H2B. Here we show that in Plasmodium falci...
ORGANISM(S): Plasmodium falciparum 3D7 
2013-03-05 | E-GEOD-39702 | biostudies-arrayexpress
TranscriptomicsTranscription profile of the Plasmodium falciparum intraerythrocytic cycle
This experiment characterizes the transcriptome of the human malaria parasite, P. falciparum at 8 different stages of the intraerythrocytic cycle Examination of polyA selected RNA in Plasmodium falciparum 3D7 strain at 8 different stages using RNA-seq
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23865 | biostudies-arrayexpress
GenomicsEpigenetic profile of the Plasmodium falciparum intraerythrocytic cycle
This experiment characterizes the localisation of H2A.Z, H3K9ac and H3K4me3 in the epigenome of the human malaria parasite, P. falciparum at 4 different stages of intraerythrocytic development. Examination of H2A.Z, H3K9ac, H3K4me3 and mono-nucleosomal input in 3D7 strain at 4 different stages and H...
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23867 | biostudies-arrayexpress
TranscriptomicsRepresentative Illumina sequencing libraries upon T7-polymerase based amplification
This experiment highlights the extreme sequence bias generated by standard PCR amplication of sequencing libraries and decribes an adapted T7-polymerase based amplification method, which results in non-baised, representative libraries for Illumina sequencing Adaptation of standard Illumina sequencin...
ORGANISM(S): Plasmodium falciparum 3D7 
2010-10-28 | E-GEOD-23868 | biostudies-arrayexpress
TranscriptomicsIntegrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression
Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilisation in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here we report the first transcr...
ORGANISM(S): Plasmodium falciparum 
2016-06-28 | E-GEOD-75795 | biostudies-arrayexpress
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