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TranscriptomicsAsporin is Expressed at Higher Levels in the More Degenerate Human Intervertebral Disc Tissue
Asporin, also known as periodontal ligament-associated protein 1 (PLAP1), is a member of the family of small leucine-rich proteoglycan (SLRP) family. It is present within the cartilage extracellular matrix (ECM), and is reported have a genetic association with osteoarthritis. Its D14 allele has rec...
ORGANISM(S): Homo sapiens 
2009-03-24 | E-GEOD-15227 | biostudies-arrayexpress
TranscriptomicsGene Expression Data from Senescent vs Non-senescent Cells in the in Vivo Human Annulus
The presence of senescent cells in the aging/degenerating human disc is now well-recognized. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue, however, offers a special challenge since the...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-GEOD-17077 | biostudies-arrayexpress
TranscriptomicsIL-1 Exposure Significantly increases gene expression of BDNF, NTF3 and NRP2 as well as NGF Production in Human Annulus Cells
Although the degenerating disc is considered to be the key source of pain in patients with low back pain, the relationship between disc cells, nerves, and pain production is poorly understood. Neurotrophins are signaling molecules involved in the survival, differentiation, migration, and neurite ou...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-27494 | biostudies-arrayexpress
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