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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownTherapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
Not available
S-EPMC4962737 | biostudies-literature
UnknownAssessing olaparib efficacy in U.S. Veterans with metastatic prostate cancer utilizing a time-indifferent g-rate method ideal for real-world analyses.
Not available
S-EPMC11388178 | biostudies-literature
MetabolomicsComplete pathway elucidation and heterologous reconstitution of Rhodiola salidroside biosynthesis
Salidroside is a bioactive tyrosine-derived phenolic natural product found in medicinal plants under the Rhodiola genus. In addition to their roles in traditional medicine as anti-fatigue and anti-anoxia adaptogens, Rhodiola total extract and salidroside have also displayed medicinal properties as a...
2018-01-25 | MTBLS566 | MetaboLights
TranscriptomicsClonal Analysis for Identification of Molecular Pathways with Potential Therapeutic Implications in of Rare Gastrointestinal and Endocrine Cancers
Genomic analysis of many cancers has led to the identification of novel targets and the development of personalized, targeted therapies. Unfortunately, in the majority of rare tumors, this type of analysis can be particularly challenging. Large series of specimens for analysis are simply not availab...
ORGANISM(S): Homo sapiens 
2012-03-31 | E-GEOD-34063 | biostudies-arrayexpress
UnknownA 20-kb lineage-specific genomic region tames virulence in pathogenic amphidiploid Verticillium longisporum.
Not available
S-EPMC8295516 | biostudies-literature
UnknownGermline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability.
Not available
S-EPMC6218849 | biostudies-literature
TranscriptomicsPancreatic Tumor vs Various Tissue Normals
Pancreatic Tumor samples from biopsy collected at different stages along with normal tissue samples from various organ sites including commercial normals arrayed on 2channel Agilent 60mer Oligo arrays (human v1 & v2), median normalized for cross comparison. Some normal samples temporarily removed to...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-11838 | biostudies-arrayexpress
TranscriptomicsDeep Clonal Profiling of Formalin-Fixed Paraffin-Embedded Clinical Samples
Formalin-fixed paraffin-embedded (FFPE) tissues are a vast resource of annotated clinical samples. As such, they represent highly desirable and informative materials for the application of high-definition genomics for improved patient management and to advance the development of personalized therape...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-40299 | biostudies-arrayexpress
TranscriptomicsRobust Molecular Classification of Ependymal Tumors Across All Anatomic Compartments
Ependymal tumors across age groups have been classified solely by histopathology. It is, however, commonly accepted that this classification has limited clinical utility based on its poor reliability. We aimed at establishing a reliable and reproducible molecular classification using DNA methylation...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-65362 | biostudies-arrayexpress
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