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TranscriptomicsClariomS Array to determine the impact of whole body adenylyl cyclase 5 (Adcy5) knockout on male/female epigonadal white adipos tissue (eWAT) gene expression
We analyzed the effect of whole body Adcy5 knockout on adipose tissue gene expression profiles. Therefore, we isolated RNA, examined RNA integrity and concentration on an Agilent Fragment Analyzer using the HS RNA Kit. cRNA was prepared from 100 ng of total RNA hybridized to GeneChip Clariom S array...
ORGANISM(S): Mus musculus 
2021-04-19 | E-MTAB-9417 | biostudies-arrayexpress
TranscriptomicsClariomS Array to determine the effect of a vaspin-derived peptide on gene expression in fully differentiated primary subcutaneous mouse adipocytes
Screening for potential target proteases of vaspin revealed rapid and specific cleavage within the vaspin N-terminus, releasing short peptides with cell penetrating activity. For microarray analysis to determine the effect of a vaspin-derived peptide on gene expression in adipocytes, fully different...
ORGANISM(S): Mus musculus 
2021-03-31 | E-MTAB-9592 | biostudies-arrayexpress
TranscriptomicsClariom S mouse arrays of C57Bl6/NTac mice to analyse how obesogenic diet exposure of parents induces sex-specific programming of overweight in mouse offspring
The arrays were used to explore how parents’ obesity status influence their offspring’s weight. We randomly assigned three-week-old mice to two groups, one group receiving a high-fat diet (HFD), the other group receiving a control diet  (chow). Adult females of both groups were mated to males fed wi...
ORGANISM(S): Mus musculus 
2023-11-30 | E-MTAB-13493 | biostudies-arrayexpress
TranscriptomicsClariomS Array to Investigate Vaspin Transgenic Mice: Assessing the Impact of (Brown) Adipocyte Vaspin Expression on Thermoregulation and Brown Adipose Tissue Thermogenesis
Vaspin previously was identified as part of the secretome of activated brown adipose tissue in mice. For microarray analysis and to determine the effect of adipocyte-sepcific vaspin overexpression on transcriptional changes during acute cold exposure, brown adipose tissue of female vaspin transgenic...
ORGANISM(S): Mus musculus 
2024-08-31 | E-MTAB-14068 | biostudies-arrayexpress
TranscriptomicsClariom S Mouse Arrays of adult male control, mT3, or TRb-/- offsprings in intrascapular brown adipose tissue
Microarray study of iBAT gene expression comparing a) adult male offspring of control and 3,3’,5-triiodothyronine (T3)-treated mothers during pregnancy and b) adult male offspring of control and maternal thyroid hormone receptor (TR) β signaling (TRb) treated mothers during pregnancy. Microarrays we...
ORGANISM(S): Mus musculus 
2023-06-21 | E-MTAB-12587 | biostudies-arrayexpress
TranscriptomicsIllumina methylation EPIC arrays of human blood at baseline and after 18 months of dietary interventions
To highlight molecular mechanisms underlying the beneficial metabolic effects of a Mediterranean (MED) diet, a MED diet enriched in polyphenols and reduced in red/processed meat (greenMED), and a diet with healthy dietary guidelines (HDG), we analyzed their effects on the methylome in the 18-month D...
ORGANISM(S): Homo sapiens 
2023-07-23 | E-MTAB-12527 | biostudies-arrayexpress
TranscriptomicsHuman Illumina 850K EPIC methylation arrays of blood, subcutaneous and omental visceral adipose tissue from two-step surgical approach
Genome wide DNA methylation in blood, subcutaneous and omental visceral adipose tissue from two-step surgical approach (N=9) was analysed in patients with severe obesity using Illumina 850K EPIC technology before and after metabolic surgery (Leipzig Obesity BioBank (LOBB) cohort). Additionally, a va...
ORGANISM(S): Homo sapiens 
2024-03-31 | E-MTAB-13564 | biostudies-arrayexpress
TranscriptomicsClariomS Array to determine differential gene expression in brown adipose tissue in myoglobin-knockout mice and controls after cold exposure.
Whole-body myoglobin knockout mice on NMRI background and NMRI controls were exposed to cold (8°C) for 6 hours and gene expression was analyzed in interscapular BAT.
ORGANISM(S): Mus musculus 
2022-06-30 | E-MTAB-11059 | biostudies-arrayexpress
UnknownWHO grade has no prognostic value in the pediatric high-grade glioma included in the HERBY trial.
Not available
S-EPMC6954414 | biostudies-literature
TranscriptomicsMatrix Elasticity Does Not Affect Replicative Senescence or DNA Methylation Patterns of Mesenchymal Stem Cells [DNAm profiling]
Matrix elasticity influences differentiation of mesenchymal stem cells (MSCs) but it is unclear if these effects are only transient - while the cells reside on the substrate - or if they reflect persistent lineage commitment. In this study, MSCs were continuously culture-expanded in parallel either ...
ORGANISM(S): Homo sapiens 
2014-07-29 | E-GEOD-55888 | biostudies-arrayexpress
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