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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownData-driven exploration of weak coordination microenvironment in solid-state electrolyte for safe and energy-dense batteries.
Not available
S-EPMC11772685 | biostudies-literature
ProteomicsPre-Analytical Framework for Routine Clinical Use of Liquid Biopsies: Combining EVs and cfDNA
Liquid biopsies hold significant potential for the non-invasive diagnostics of tumors and other diseases. While the clinical application of cell-free DNA (cfDNA) methodologies is emerging, the implementation of tumor-derived extracellular vesicles (EVs) as validated biomarkers is hindered by substan...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD062837 | Pride
Extracellular vesicles Liquid biopsy Cfdna Human plasma Tube preservation Isolation protocol Pre-analytics Translation 
UnknownIn Silico Pan-Cancer Analysis Reveals Prognostic Role of the Erythroferrone (ERFE) Gene in Human Malignancies.
Not available
S-EPMC9864255 | biostudies-literature
ProteomicsA translational protocol for the analysis of plasma-derived extracellular vesicle proteomics
We establish here an EV purification and proteomic analysis workflow in a real world clinical setting in which we evaluate different variables, from blood collection through protein preparation for mass spectrometry (MS). We compare blood collection tubes, sample transportation and storage condition...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD058373 | Pride
Protocol Proteomics Preanalytics Liquid biopsy Plasma Extracellular vesicles Translation 
UnknownOffenders and non-offenders with schizophrenia spectrum disorders: the crime-preventive potential of sufficient embedment in the mental healthcare and support system
Not available
S-EPMC10498463 | biostudies-literature
UnknownChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum.
Not available
S-EPMC5248491 | biostudies-literature
UnknownSediment fluxes rather than oxic methanogenesis explain diffusive CH4 emissions from lakes and reservoirs.
Not available
S-EPMC6338738 | biostudies-literature
UnknownPreclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes.
Not available
S-EPMC8727300 | biostudies-literature
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