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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
ProteomicsEffect of POR knockdown on the proteome of HepaRG cells
Cytochrome P450 oxidoreductase (POR) is involved in the oxidative metabolism of xenobiotics and endogenous compounds like fatty acid and cholesterol. While effects of diminished Por were extensively studied in mouse models, studies in human models are still missing. We used previously established CR...
ORGANISM(S): Homo sapiens (Human) 
2021-11-04 | PXD028577 | Pride
Proteomics Heparg Bile acid metabolism Crispr/cas9 Cholesterol biosynthesis Nadph cytochrome p450 reductase 
GenomicsAffymetrix_miRNA4.0
Primary renal cell carcinoma (RCC) by Affymetrix GeneChip miRNA 4.0
EGAD00010001564 | EGA
GenomicsPDX_HTA2.0_Guergen2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) and RCC metastases related to Guergen et al, Front Oncol 12:2022 889789. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.34.0). Probe sets were summarized on the Entrez GeneID level usin...
EGAD00010002392 | EGA
GenomicsAffymetrix_HTA2.0
Primary renal cell carcinoma (RCC) and RCC metastases by Affymetrix GeneChip HTA 2.0
EGAD00010001589 | EGA
GenomicsRCC_HTA2.0_Reustle2020
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Reustle et al, Genome Med 12:2020 32. Preprocessing of microarray data was performed using Robust Multi-array Average (RMA).
EGAD00010002323 | EGA
GenomicsRCC_HTA2.0_Buettner2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Buettner et al, Genome Med 2022. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.26.0, R version 3.6.1). Probe sets were summarized on the Entrez GeneID level using the annota...
EGAD00010002353 | EGA
GenomicsRCC_HTA2.0_Reustle2022
GeneChip HTA 2.0 data of primary renal cell carcinoma (RCC) related to Reustle et al., Clin Transl Med 12:2022 e883. Microarrays were normalized individually using the SCAN method from the R package SCAN.UPC (version 2.26.0, R version 3.6.1). Probe sets were summarized on the Entrez GeneID level usi...
EGAD00010002352 | EGA
GenomicsIllumina_450K
Primary renal cell carcinoma (RCC), RCC metastases and cell lines by Illumina 450K
EGAD00010001001 | EGA
GenomicsStudy of renal cancers and renal cancer metastases
Study of primary renal cancers as well as metastases derived from renal cancers in various distant organs.
EGAS00001001176 | EGA
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