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GenomicsMultiple roles for Grainyhead-like transcription factors in the establishment and maintenance of human mucociliary airway epithelium (ChIP-Seq)
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-46194 | biostudies-arrayexpress
TranscriptomicsMultiple roles for Grainyheadlike transcription factors in the establishment and maintenance of human mucociliary airway epithelium
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-44718 | biostudies-arrayexpress
TranscriptomicsGene expression data from primary human bronchial epithelial cells expressing EGFP or DN-GRHL2
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ progenitors. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-44807 | biostudies-arrayexpress
TranscriptomicsGene expression data from primary human bronchial epithelial cells expressing EGFP or DN-GRHL2 for 48h
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-44808 | biostudies-arrayexpress
TranscriptomicsAge-related changes in the cellular composition and epithelial organization of the mouse trachea
We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and the main stem bronchi. We confirm previous reports of the graduate appearance of age-related, gland-like structures (ARGLS) in the submucosa, espeically in the i...
ORGANISM(S): Mus musculus 
2014-02-20 | E-GEOD-55162 | biostudies-arrayexpress
TranscriptomicsGene expression data from mouse tracheal mesenchymal cells before and 48hrs after SO2 injury
The conducting airway epithelium of the rodent and human lung is underlaid by mesenchymal cells that include vasculature, smooth muscle, fibroblasts and cartilage. The goal of this project is to identify cellular and molecular changes in the mesenchyme after injury to the epithelium by exposure to S...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-69057 | biostudies-arrayexpress
TranscriptomicsGene expression data from mouse tracheal epithelial cells isolated before and 48hrs after SO2 injury
The conducting airway epithelium of the rodent and human lung is made up of about equal proportions of ciliated and secretory cells. In addition, in regions where the epithelium is pseudostratfied, ~30% of the epithelium consists of undifferentiated basal cells (BCs). Evidence suggests that these BC...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-69056 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling reveals similarities and differences among mouse pluripotent stem cells
We present a compendium DNA microarray analysis of multiple mouse ESCs and EGCs from different genetic backgrounds (strains 129 and C57BL/6) cultured under standard conditions and in differentiation-promoting conditions by the withdrawal of Leukemia Inhibitory Factor (LIF) or treatment with retinoic...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-5914 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse nmyc misexpression in lung (gain of function)
Understanding how lung progenitor cells balance; proliferation against differentiation is relevant to clinical; disorders such as bronchopulmonary dysplasia of; premature babies and lung cancer. Previous studies have; established that lung development is severely disrupted in; mouse mutants with red...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6077 | biostudies-arrayexpress
UnknownGRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells
Not available
S-JCBD-201506014 | bioimages
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