Sort   by:  
 Page size 
TranscriptomicsGlobal gene expression response in peripheral blood cells of petroleum workers exposed to very low benzene levels
Benzene, a natural component of petroleum products, is a known hematotoxic and leukemogenic agent. The haematotoxic effect and excess leukemia has been reported below 1 ppm, an exposure level previously considered not to cause any health effects. Gene expression studies suggest that benzene affects ...
ORGANISM(S): Homo sapiens 
2017-10-19 | E-MTAB-5331 | biostudies-arrayexpress
TranscriptomicsOverexpression of Integrin α11 Induces Cardiac Fibrosis in Mice
The integrin α11-overexpressing transgenic mouse strain was generated to further understand the function of α11, after generation of our integrin α11-KO strain. Analysis of the strain showed that integrin α11 was highly expressed in heart, which correlated with a fibrotic heart phenotype. To und...
ORGANISM(S): Mus musculus 
2017-08-31 | E-MTAB-5040 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by microarray of A549 cells and Ext1 knock out or wild type mouse embryonic fibroblast cells co-cultured as spheroids
Determine differentially expressed human genes in A549 tumors when co-cultured in spheroids with mouse fibroblast harbouring a mutation in the heparan sulphate elongation enzyme Ext1 compared to corresponding wild-type fibroblast/A549-containing spheroids.
ORGANISM(S): Homo sapiens 
2018-04-04 | E-MTAB-5874 | biostudies-arrayexpress
TranscriptomicsTamoxifen treatment of MCF-7 breast cancer cells
Tamoxifen is an anti-estrogen drug used in the treatment of Estrogen Receptor (ER) positive breast cancer. Effects and side effects of tamoxifen is the sum of tamoxifen and all its metabolites. Using concentrations that mimic the clinical situation we examined effects of 4OHtam, 4OHNDtam and NDtam o...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-MTAB-2729 | biostudies-arrayexpress
TranscriptomicsIntegrin_a11_knockout
The project is to study how the expression of integrin alpha11beta1 on stromal cells (MEFs) affects the tumor cell behavior (A549 cells) in a heterospheroid co-culture model. We have found that the fibroblast alpha11beta1 integrin affects compaction and interstitial fluid pressure of the heterospher...
2014-07-03 | E-MTAB-2687 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of human osteosarcomas of primary and metastatic origin reveals alterations in chemokine pattern
Global gene expression analysis was performed on a panel of 23 osteosarcoma samples of primary and metastatic origin using the Applied Biosystems Gene Expression Array System. When comparing the primary tumours with the metastases, we found a significantly increased expression of genes involved in i...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-32981 | biostudies-arrayexpress
GenomicsGSA QCed data
QC-ed data of 9,534 DDD Study participants, including 8,879 individuals with inferred GBR ancestry. Details of genotype QC can be found in https://www.medrxiv.org/content/10.1101/2023.04.20.23288860v1.full.pdf. Genome builds are indicated in the file name. Related individuals have not been removed. ...
EGAD00010002568 | EGA
GenomicsSC_DDD-G-3
Unfiltered genotype data for DDD Study trios (patient and parents) (N=2,166 samples), some of which were used for replication of neurodevelopmental disorder polygenic risk (Niemi et al., Nature 2018). Samples were genotyped on the Illumina HumanOmniExpress BeadChip
EGAD00010001602 | EGA
Genomicsena-DATASET-SC-30-04-2015-15:06:30:503-5 - samples
DDD DATAFREEZE 2013-12-18: 1133 trios - VCF files (Ref: DDD Nature 2015)
EGAD00001001355 | EGA
GenomicsGSA pilot raw data
Unfiltered genotype data for a pilot study (Batch 1) of 1,140 DDD Study participants (and 12 "Empty" samples). Samples include 380 mothers, 382 fathers and 378 probands, and form 376 trios. Most of the probands have been previously genoyped on the llumina HumanCoreExome BeadChip (EGAD00010...
EGAD00010002567 | EGA
Sort   by:  
 Page size