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MetabolomicsChemotherapy Modulation by a Cancer-Associated Microbiota Metabolite (Targeted metabolomics - fluoronucleotides)

Understanding how the microbiota produces regulatory metabolites is of significance for cancer and cancer therapy. Using a host-microbe-drug-nutrient 4-way screening approach, we evaluated the role of nutrition at the molecular level in the context of 5-fluorouracil toxicity. Notably, our screens...

2025-09-16 | MTBLS9991 | MetaboLights
TranscriptomicsBulk RNA-seq of untreated human cell lines from multiple tissues
Bulk RNA-seq profiling of untreated human cell lines derived from blood, breast and bladder tissues (MCF7, MDA-MB-231, KMCB2, Jurkat) to characterise baseline transcriptional differences across cellular contexts.
ORGANISM(S): Homo sapiens 
2026-01-25 | E-MTAB-16514 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of ERα-positive breast cancer cell lines to measure the interplay of fulvestrant treatment and hypoxic conditions
Estrogen receptor alpha (ERα) and hypoxia-inducible factors (HIFs) are key regulators of transcriptional programmes in breast cancer. To investigate their interplay, we performed RNA sequencing on ERα-positive breast cancer cell lines (MCF-7 and T-47D) following treatment with the selective estrogen...
ORGANISM(S): Homo sapiens 
2025-07-21 | E-MTAB-15331 | biostudies-arrayexpress
GenomicsChIP-seq of ERα in MCF7 cells treated with the hypoxia mimetic DMOG versus vehicle control
While many studies have investigated the effects of hypoxia on the progression of ER-positive (ER⁺) breast cancer, the impact of hypoxia on estrogen receptor alpha (ERα) signalling remains relatively understudied. In this dataset, we examine how the hypoxia mimetic DMOG influences ERα chromatin bind...
ORGANISM(S): Homo sapiens 
2025-07-21 | E-MTAB-15329 | biostudies-arrayexpress
UnknownMolecular Characterization and Biocompatibility of Exopolysaccharide Produced by Moderately Halophilic Bacterium Virgibacillus dokdonensis from the Saltern of Kumta Coast.
Not available
S-EPMC9570845 | biostudies-literature
UnknownWarming, Snow Exclusion, and Soil Type Alter the Timing of Plant and Soil Activity and Associated Nutrient Losses.
Not available
S-EPMC12365583 | biostudies-literature
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
TranscriptomicsMice Exposed in situ to Urban Air Pollution Exhibit Pulmonary Alterations in Lipid Droplet Synthesis Pathways
In the present study, we investigate pulmonary transcriptional responses in mice following exposure in situ to ambient air in a heavily polluted urban environment. Mature C57BL/CBA male mice were caged in sheds located in an urban area near two working steel mills and a major highway in Hamilton, On...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-41698 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic kidney cells expressing apoptosis inducing proteins, time series
Three apoptosis inducing proteins, ACO1, STK3 and XBP1 were discovered in a previous reverse transfection screen. HEK293T cells were harvested and RNA extracted from the cells after over-expression of these 3 proteins at 12, 24 and 48 hours. A positive apoptosis inducer staurosporine and a negative ...
ORGANISM(S): Homo sapiens 
2005-09-05 | E-MEXP-421 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 10 sample types: normal colon tissue, non cancerous adenomas, Dukes B carcinomas, Dukes C carcinomas, Dukes D carcinomas, and liver metastases, see also E-TIGR-14, E-TIGR-15
This study was designed to find patterns of gene expression in colon cancer samples that correlate with clinical stage. Ten samples were profiled from each of the following sample types: normal colon tissue, noncancerous adenomas, Dukes B carcinomas, Dukes C carcinomas, Dukes D carcinomas, and liver...
ORGANISM(S): Homo sapiens 
2005-01-01 | E-TIGR-14 | biostudies-arrayexpress
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