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TranscriptomicsTranscription profiling of human tumor-conditioned versus quiescent HUVEC cells, and 5-aza-2a??-deoxycytidine and trichostatin AI treated cells to identify epigenetically silenced genes
Tumor angiogenesis requires intricate regulation of gene expression in endothelial cells (EC). We recently showed that DNA methyltransferase (DNMT)- and histone deacetylase (HDAC) inhibitors directly repress EC growth and tumor angiogenesis, suggesting that epigenetic modifications mediated by DNMTs...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7132 | biostudies-arrayexpress
TranscriptomicsEffect of neurotrophin p75 receptor (p75NTR) on angiogenesis
Neurotrophins (NTs) promotes angiogenesis and EC survival, via tropomyosin kinase trkA and trkB receptors. A different p75NTR receptor of NTs, which belongs to the TNF-alfa receptor superfamily, is not or scarcely expressed by endothelial cells (EC) and endothelial progenitor cells (EPC) under basal...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-9910 | biostudies-arrayexpress
TranscriptomicsCandidate pathways for promoting differentiation and quiescence of oligodendrocyte progenitor-like cells in glioblastoma
The mature CNS contains PDGFRA+ ‘oligodendrocyte progenitor cells’ (OPC) which may remain quiescent, proliferate, or differentiate into oligodendrocytes. In human gliomas, rapidly proliferating Olig2+ cells resembling OPCs are frequently observed. We sought to identify, in vivo, candidate pathways u...
ORGANISM(S): Mus musculus 
2012-10-04 | E-GEOD-30626 | biostudies-arrayexpress
UnknownHLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.
Not available
S-EPMC8042025 | biostudies-literature
TranscriptomicsSimultaneous Host-Pathogen transcriptome analysis during Granulibacter bethesdensis infection of normal and chronic granulomatous disease neutrophils
Polymorphonuclear leukocytes (PMN) from patients with chronic granulomatous disease (CGD) fail to produce microbicidal concentrations of reactive oxygen species due to mutations in NOX2. Patients with CGD suffer from severe, life-threatening infections and inflammatory complications. Granulibacter...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-55849 | biostudies-arrayexpress
TranscriptomicsInnate Immune Recognition of Bacterial Viability Instructs Human T follicular Helper Cell Differentiation
Live attenuated vaccines are often superior to dead vaccines, yet the immunological mechanisms remain largely obscure. We have recently uncovered an inherent capacity of antigen-presenting cells (APC) to discriminate live from killed bacteria by virtue of vita-PAMPs. Here we found that innate recogn...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-68255 | biostudies-arrayexpress
UnknownPsychopharmacology in children with genetic disorders of epigenetic and chromatin regulation.
Not available
S-EPMC12023381 | biostudies-literature
UnknownWnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma.
Not available
S-EPMC7261487 | biostudies-literature
TranscriptomicsAgilent 244K aCGH data for colon cancer samples
Mutation of the gene PARK2 is the most common cause of early-onset Parkinson's Disease (PD)1,2. PARK2 encodes a gene product with E3 ubiquitin ligase activity3. In a search for multisite tumor suppressors, we identified PARK2 as a frequently targeted gene on chromosome 6q25.2-q27 in cancer. Here,...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-18638 | biostudies-arrayexpress
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
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