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TranscriptomicsGene expression in soleus muscle of mouse inbred strains LG/J and SM/J
Variability in muscle mass significantly impacts energy expenditure, influencing preponderance to obesity and recently it has been reported that there is a positive association between muscle mass and longevity in older adults. Muscle fibre cross-sectional area (CSA) and proportion of different fibr...
ORGANISM(S): Mus musculus 
2017-01-23 | E-MTAB-5290 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neutrophils exposed to S. aureus infection
Neutrophil lysis after phagocytosis is a process potentially important in the pathogenesis of community-associated methicillin-resistant S. aureus (CA-MRSA) infection. The mechanism for this process is not currently known. Therefore, to better understand CA-MRSA virulence we used human oligonucleo...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-16837 | biostudies-arrayexpress
TranscriptomicsSodium arsenite induced gene expression changes in A549 human epithelial lung carcinoma cells
Arsenic is methylated during its metabolism, thereby depleting the intracellular methyl donor S-adenosyl-methionine, which may lead to disturbances in DNA methylation patterns which could lead to altered gene expression Cells were exposed to sodium arsenite (NaAsO2, Sigma) at concentrations of 0.08 ...
ORGANISM(S): Homo sapiens 
2014-09-17 | E-GEOD-44169 | biostudies-arrayexpress
TranscriptomicsA Saccharomyces cerevisiae strain with a minimal complement of glycolytic genes reveals strong redundancies in central metabolism
As a result of ancestral whole genome and small-scale duplication events, the genome of Saccharomyces cerevisiaeM-bM-^@M-^Ys, and of many eukaryotes, still contain a substantial fraction of duplicated genes. In all investigated organisms, metabolic pathways, and more particularly glycolysis, are spe...
ORGANISM(S): Saccharomyces cerevisiae 
2014-12-06 | E-GEOD-63884 | biostudies-arrayexpress
UnknownSUPRAMAX-study: supramaximal resection versus maximal resection for glioblastoma patients: study protocol for an international multicentre prospective cohort study (ENCRAM 2201).
Not available
S-EPMC11086386 | biostudies-literature
TranscriptomicsOverexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity
Aims/hypothesis: While lipid deposition in skeletal muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We previously demonstrated that overexpression of the lipid drop...
ORGANISM(S): Rattus norvegicus 
2013-01-29 | E-GEOD-43832 | biostudies-arrayexpress
UnknownPriming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone.
Not available
S-EPMC1865796 | biostudies-literature
GenomicsAsymmetry of STAT action in driving IL-27 and IL-6 transcriptional outputs and cytokine specificity
IL-6 and IL-27 have antagonistic and overlapping functions, signal through a shared receptor subunit and employ the same downstream STAT proteins. To evaluate the degree of specificity and redundancy for these cytokines, we quantified global transcriptomic changes induced by the two cytokines and de...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-65621 | biostudies-arrayexpress
UnknownLong-term prognosis of young breast cancer patients (≤40 years) who did not receive adjuvant systemic treatment: protocol for the PARADIGM initiative cohort study.
Not available
S-EPMC5695414 | biostudies-literature
UnknownMechanically resilient hybrid aerogels containing fibers of dual-scale sizes and knotty networks for tissue regeneration.
Not available
S-EPMC10844217 | biostudies-literature
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