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ProteomicsBone marrow-selected antigen specific regulatory B cells
Autoimmunity is often regarded as pathogenic, but this view has gradually shifted over time. Based on insights from thymus selection, T cells are now known to be selected by self-antigens and positive selection in the thymus medulla leads to regulatory functions. B cells are selected in the bone mar...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-13 | PXD025837 | Pride
Breg Lc-ms/ms Facs Mouse 
ProteomicsA peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells
A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. Major hindrances have so far been to select natural regulatory antigen targets and side-effects induced by clustering the T cell receptor (TCR) or activating the costimulatory signa...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-15 | PXD034792 | Pride
Autoimmune arthritis Arthritis Antigen-specific t cells Vaccine 
MetabolomicsReactive Oxygen Species Deficiency Due to Ncf1-Mutation Leads to Development of Adenocarcinoma and Metabolomic and Lipidomic Remodeling in a New Mouse Model of Dextran Sulfate Sodium-Induced Colitis
Inflammatory bowel disease is characterized by chronic relapsing idiopathic inflammation of the gastrointestinal tract and persistent inflammation. Studies focusing on the immune-regulatory function of reactive oxygen species (ROS) are still largely missing. In this study, we analyzed an ROS-deficie...
2019-05-22 | MTBLS593 | MetaboLights
ProteomicsAuranofin Fosters Regulatory T Cell Expansion and Augmented Tumor Burden in Mice
Auranofin, an FDA-approved antirheumatic drug, has been reported to have anti-tumoral properties but its immunological effects and significance are not well understood. This study is the first to report auranofin-induced regulatory T cell (Treg) expansion. In a mouse model with B16F10 melanoma, aura...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD069997 | Pride
Mouse model Treg Auranofin 
ProteomicsAuranofin Fosters Regulatory T Cell Expansion and Augmented Tumor Burden in Mice
Auranofin, an FDA-approved antirheumatic drug, has been reported to have anti-tumoral properties but its immunological effects and significance are not well understood. This study is the first to report auranofin-induced regulatory T cell (Treg) expansion. In a mouse model with B16F10 melanoma, aura...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-08 | PXD060423 | Pride
Thioredoxin reductase 1 (trxr1) Nrf2 Immune response Treg B16f10 Auranofin 
ProteomicsPolymorphism in estrogen receptor binding site causes CD2-dependent sex bias in T cell autoimmune diseases
Complex autoimmune diseases are sexually dimorphic. An interplay between predisposing genetics and sex-related factors likely determines the sex discrepancy in the immune response, but conclusive evidence regarding the underlying molecular mechanisms is lacking. Using forward genetics, we positional...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-15 | PXD024126 | Pride
Estrogen receptor Sexual dimorphism Autoimmune diseases 
ProteomicsA novel non-galactosylated tolerogenic antigen-specific vaccine protects against arthritis via VISTA-expressing regulatory T cells in DRB1*04:01 mice
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, cartilage damage and bone erosion. Despite improvements with the introduction of biological disease-modifying anti-rheumatic drugs (DMARDs), RA remains incurable. Advancements in peptide-based vaccination...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD056818 | Pride
Vaccine Arthritis Mice Immune cells 
ProteomicsArthritis protection conferred by a subset of antibodies to citrullinated proteins in rheumatoid arthritis - human synovium fluids samples
Anti-citrullinated protein antibodies (ACPAs) are one of the hallmarks in rheumatoid arthritis (RA), but the in vivo function remained unclear. To investigate the effects of ACPAs, we expressed monoclonal ACPAs derived from RA patients, and analyzed the functions in mouse models, as well as the reac...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD035180 | Pride
Anti-citrullinated protein antibodies Rheumatoid arthritis Autoimmune 
ProteomicsArthritis protection conferred by a subset of antibodies to citrullinated proteins in rheumatoid arthritis - macrophage samples
Anti-citrullinated protein antibodies (ACPAs) are one of the hallmarks in rheumatoid arthritis (RA), but the in vivo function remained unclear. To investigate the effects of ACPAs, we expressed monoclonal ACPAs derived from RA patients, and analyzed the functions in mouse models, as well as the reac...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-09 | PXD035177 | Pride
Anti-citrullinated protein antibodies Rheumatoid arthritis Autoimmune 
no omics definedTranscription profiling of submandibular salivary glands from mice congenic for the two chromosomal regions Nss1 and Idd5
Gene expression profiling and sialadenitis scoring in submandibular salivary glands from mice congenic for the two chromosomal regions Nss1 and Idd5.
ORGANISM(S): Mus musculus 
2007-09-26 | E-BASE-6 | biostudies-arrayexpress
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