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TranscriptomicsTranslational profiling of hypocretin neurons identifies Lhx9 as necessary for normal development of the hypocretinergic system.
The immense molecular diversity of neurons challenges our ability to deconvolve the relationship between the genetic and the cellular underpinnings of neuropsychiatric disorders. Hypocretin (orexin) containing neurons of the lateral hypothalamus are clearly essential for the normal regulation of sle...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-38668 | biostudies-arrayexpress
ProteomicsHuman CSF peptidomics of gamma secretase inhibition
Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the ?-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080870 | MassIVE
TranscriptomicsTranscription profiling of total of rat liver samples treated with 300 mg/kg/day myclobutanil, 300 mg/kg/day propiconazole, and 175 mg/kg/day triadimefon
The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was ...
ORGANISM(S): Rattus norvegicus 
2008-04-08 | E-GEOD-10409 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver treated with myclobutanil or triadimefon triazole antifungals
The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was ...
ORGANISM(S): Rattus norvegicus 
2008-04-09 | E-GEOD-10408 | biostudies-arrayexpress
TranscriptomicsCHSA transcriptional profiles
Transcriptional profiling of preangiogenic and angiogenic tumor nodules was conducted to identify genes that were differentially expressed during the transition from the preangiogenic to the angiogenic phenotype.
ORGANISM(S): Rattus norvegicus 
2013-01-24 | E-MEXP-3775 | biostudies-arrayexpress
UnknownHigh affinity interactions and signal transduction between Aβ oligomers and TREM2
Not available
S-SCDT-EMM-2018-09027 | biostudies-other
UnknownC9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Not available
S-EPMC8298293 | biostudies-literature
TranscriptomicsIdentification of drugs that enhance skin repair using dermal stem cell-based screens [Rat]
Here, we asked whether we could identify pharmacological agents that enhance endogenous stem cell function to promote skin repair, focusing on SKPs (skin-derived precursors) a dermal precursor cell population. Libraries of compounds already used in humans were screened for their ability to enhance t...
ORGANISM(S): Rattus norvegicus 
2015-12-24 | E-GEOD-73328 | biostudies-arrayexpress
TranscriptomicsTranscriptome Profiling of Hippocampal CA1 After Early Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies for Epilepsy
Injury of the CA1 subregion induced by a single injection of kainic acid (1M-CM-^WKA) is attenuated when juvenile animals (P20) have a history of two sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early life conditioning...
ORGANISM(S): Rattus norvegicus 
2013-02-14 | E-GEOD-44031 | biostudies-arrayexpress
UnknownNovel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.
Not available
S-EPMC12187977 | biostudies-literature
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