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ProteomicsHuman CSF peptidomics of gamma secretase inhibition
Fifteen human healthy volunteers, divided into three groups, received a single dose of placebo or either 140 mg or 280 mg of the ?-secretase inhibitor semagacestat (LY450139). Endogenous peptides in CSF, sampled prior to administration of the drug and at six subsequent time points, were analyzed by ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080870 | MassIVE
UnknownC9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Not available
S-EPMC8298293 | biostudies-literature
UnknownFunctional connectivity in autosomal dominant and late-onset Alzheimer disease.
Not available
S-EPMC4240274 | biostudies-literature
TranscriptomicsTranscriptome Profiling of Hippocampal CA1 After Early Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies for Epilepsy
Injury of the CA1 subregion induced by a single injection of kainic acid (1M-CM-^WKA) is attenuated when juvenile animals (P20) have a history of two sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early life conditioning...
ORGANISM(S): Rattus norvegicus 
2013-02-14 | E-GEOD-44031 | biostudies-arrayexpress
UnknownNovel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.
Not available
S-EPMC12187977 | biostudies-literature
UnknownFine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
Not available
S-EPMC3036586 | biostudies-literature
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