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TranscriptomicsExpression data from a reversible dasatinib-resistant state in long-term dasatinib-treated c-KIT-mutated Kasumi-1 cell line
Long-term treatment of Kasumi-1 cells at clinically attained doses of dasatinib led to decreased drug-sensitivity by means of IC50 values (relative to treatment-naive cells). Changes were paralled by profound alterations in c-KIT expression and cell signaling signatures. Upon brief discontinuation o...
ORGANISM(S): Homo sapiens 
2013-11-27 | E-GEOD-39073 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genomic profiling of marginal zone B-cell lymphomas and variants
We studied marginal zone B-cell lymphomas of the gastrointestinal tract including seven small cell MALT lymphomas, eight composite lymphomas and thirteen large cell variants using SNP-array profiling. We found an increase of genomic complexity with lymphoma progression, and could identify gains of p...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-36311 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant
This SuperSeries is composed of the following subset Series: GSE27512: Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA) GSE27513: Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA) Refer to individual Series
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27514 | biostudies-arrayexpress
TranscriptomicsCharacterization of Formaldehyde's Genotoxic Mode of Action by Gene Expression Analysis in TK6 Cells
Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. This approach has been shown to differentiate between DNA reactive genotoxins and non-DNA reactive or indirectly-acting genotoxins. In this context, it has been suggested th...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-41296 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution Genomic Profiling of Chronic Lymphocytic Leukemia Reveals New Recurrent Genomic Alterations
To identify genomic alterations in chronic lymphocytic leukemia (CLL), we performed single-nucleotide polymorphism (SNP)-array analysis on 353 samples from previously untreated patients entered on the CLL8 treatment trial. Based on paired-sample analysis (n=147), a mean of 1.8 copy number alteration...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-36908 | biostudies-arrayexpress
TranscriptomicsExpression of constitutively active FOXO3 in murine forebrain leads to a loss of neural progenitors
We have generated transgenic mice with tetracycline-regulated conditional expression of a constitutively active allele of FoxO3 under the control of the forebrain-specific CaMKIIa promoter. In adult animals, there was a reduction of brain weight by 30% and an almost complete loss of the dorsal denta...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-21089 | biostudies-arrayexpress
TranscriptomicsAssessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions
41 volunteers (male non-smokers) were exposed to formaldehyde (FA) vapors for 4 h per day over a period of 5 working days under strictly controlled conditions. For each exposure day, different exposure concentrations were used in a random order ranging from 0 up to 0.7 ppm. At concentrations of 0.3 ...
ORGANISM(S): Homo sapiens 
2011-05-04 | E-GEOD-27263 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27512 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27513 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution Genomic Profiling of Adult and Pediatric Core-Binding-Factor Acute Myeloid Leukemia Reveals New Recurrent Genomic Alterations
To identify cooperating lesions in core-binding-factor acute myeloid leukemia (CBF-AML), we performed single-nucleotide polymorphism (SNP)-array analysis on 300 diagnostic and 41 relapse adult and pediatric leukemia samples. We identified a mean of 1.28 copy number alterations (CNAs) per case at dia...
ORGANISM(S): Homo sapiens 
2012-02-07 | E-GEOD-32462 | biostudies-arrayexpress
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