Sort   by:  
 Page size 
GenomicsCovalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair
Based on the hypothesis that, enhancing the local concentration of donor oligos could increase the correction rates, we generated and tested novel CRISPR-Cas9 systems, in which the DNA repair template is covalently conjugated to Cas9 (RNPD system). To validate our results from the HEK293T reporter c...
ORGANISM(S): Mus musculus 
2018-06-04 | E-MTAB-6808 | biostudies-arrayexpress
ProteomicsHuman POT1 Prevents Severe Telomere Damage Instability Induced by Homology Directed DNA Repair
The evolutionarily conserved POT1 protein binds the single stranded G-rich telomeric DNA and has been implicated in telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics discovering that the complete abs...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD016826 | Pride
Telomeres Affinity purification Mass spectrometry Homology-directed dna repair Tandem mass tags 
ProteomicsCHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair
The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1, is enriched in heterochromatin though its cellular function in these regions of the genome remain unknown. Here we show that the CHAMP complex promotes heterochromatin assembly at multiple ch...
ORGANISM(S): Hordeum vulgare (Barley) 
2025-05-07 | PXD055109 | Pride
Human 
UnknownO-GlcNAc transferase is important for homology-directed repair.
Not available
S-EPMC9884008 | biostudies-literature
GenomicsFunctional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [i53]
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [i53]
PRJNA1014449 | ENA
GenomicsFunctional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [AmpliconSeq]
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [AmpliconSeq]
PRJNA1046097 | ENA
GenomicsFunctional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [Amplicon]
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [Amplicon]
PRJNA1014454 | ENA
GenomicsSynergic homology directed recombination by PRDM9 meiotic factor
Synergic homology directed recombination by PRDM9 meiotic factor
PRJEB58704 | ENA
GenomicsFunctional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [scRNA-Seq]
Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [scRNA-Seq]
PRJNA1014491 | ENA
GenomicsCovalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair
Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair
PRJEB26955 | ENA
Sort   by:  
 Page size