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GenomicsSubtelomeric p53 Binding Prevents Accumulation of DNA Damage at Human Telomeres
Telomeres and tumor suppressor protein TP53 (p53) function in genome protection, but a direct role of p53 at telomeres has not yet been described. Here, we have identified non-canonical p53 binding sites within the human subtelomeres that suppress the accumulation of DNA damage at telomeric repeat ...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-75528 | biostudies-arrayexpress
TranscriptomicsIdentification of RNAs associated with telomeres by enChIP-RNA-Seq
Accumulating evidence suggests important roles of RNAs interacting with genomic regions in the regulation of genome functions including X chromosome inactivation and gene expression. However, no method to identify RNAs interacting with a given genomic region in a non-biased manner has been reported....
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-60425 | biostudies-arrayexpress
ProteomicsMammalian telomeres reforged with non-telomeric sequences
Telomere is a highly refined system for maintaining the stability of linear chromosomes. Most telomeres rely on simple repetitive sequences and telomerase enzymes, but in some species or telomerase-defective situations, alternative telomere lengthening (ALT) mechanism is utilized to protect chromoso...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-17 | MSV000085772 | MassIVE
ProteomicsPeroxiredoxin 1 protects telomeres from oxidative damage preserving chromosome ends for extension by telomerase
With the increase of atmospheric oxygen 2.3 billion years ago, mechanisms evolved to mitigate the toxic effects of oxygen radicals. Telomeres appear particularly susceptible to oxidative damage, which leads to cellular and organismal aging, cancer, cardiac failure and other diseases. Specific mechan...
ORGANISM(S): Homo sapiens (Human) 
2016-12-07 | PXD002626 | Pride
Peroxiredoxin 1  telomeres  oxidative damage  telomerase 
UnknownMice with hyper-long telomeres show less metabolic aging and longer lifespans.
Not available
S-EPMC6797762 | biostudies-literature
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD057112 | Pride
Telomeres Block-id Replication stress Trim24 Sumoylation 
TranscriptomicsTelomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis
We performed single-molecule telomere length and telomere fusion analysis in patients at different stages of chronic lymphocytic leukaemia (CLL). Our work identified the shortest telomeres ever recorded in primary human tissue reinforcing the concept that there is significant cell division in CLL. F...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-22016 | biostudies-arrayexpress
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD063658 | Pride
Trim24  block-id  replication stress  alt  telomeres  sumoylation 
UnknownShort and dysfunctional telomeres protect from allergen-induced airway inflammation.
Not available
S-EPMC8135011 | biostudies-literature
GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
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