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GenomicsChromatin enrichment of TRIM24, estrogen receptor and H3K4me2 in estrogen-treated and -untreated MCF7 cells
TRIM24 PHD-Bromo domains exhibit preferential binding to unmethylated H3K4 and acetylated H3K27. TRIM24 is a co-activator of estrogen receptor (ER). The results suggest that specific ER-binding sites are depleted of H3K4me2 with estrogen treatment. TRIM24 binds these sites preferentially and faci...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-24166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse spontaneous liver tumors of Trim24/TIF1a-null animals
The transcriptional coregulator Trim24 (formerly known as TIF1a) functions in mice as a liver-specific tumor suppressor. Mice carrying a null mutation in the Trim24 gene all develop hepatocellular carcinoma (HCC). We used microarrays to identify the alterations in gene expression patterns associated...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9012 | biostudies-arrayexpress
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD063658 | Pride
Trim24  block-id  replication stress  alt  telomeres  sumoylation 
TranscriptomicsNegative regulation of the IFN/STAT signaling pathway by the Trim24 tumor suppressor protein through Rara inhibition
Recent genetic studies in mice have established a key role for the nuclear receptor coregulator Trim24 in liver tumor suppression and provided evidence that Trim24 suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor alpha (Rara)-dependent transcription and cell proliferation. Howeve...
ORGANISM(S): Mus musculus 
2011-08-01 | E-GEOD-19675 | biostudies-arrayexpress
ProteomicsReadout of histone methylation by Trim24 locally restricts chromatin opening by p53
The genomic binding sites of the transcription factor (TF) and tumour suppressor p53 are unusually diverse in regards to their chromatin features, including histone modifications, opening the possibility that chromatin provides context-dependence for p53 regulation. Here, we show that the ability of...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD039553 | Pride
Trim24 p53 mouse 
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD057112 | Pride
Telomeres Block-id Replication stress Trim24 Sumoylation 
ProteomicsComparative proteomic profiling of neonatal rat ventricular cardiomyocytes (NRVCMs) following TRIM24 overexpression
TRIM24 (Tripartite Motif-Containing 24) is a key transcriptional co-regulator involved in various cellular processes, including chromatin remodeling and gene expression. However, its role in cardiomyocytes remains largely unexplored. In this study, we investigated the global proteomic changes associ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD064832 | Pride
Trim24 Rat Neonatal rat ventricular cardiomyocytes Lc-ms/ms 
ProteomicsComparative proteomic profiling of neonatal rat ventricular cardiomyocytes (NRVCMs) following TRIM24 downregulation
TRIM24 (Tripartite Motif-Containing 24) is a key transcriptional co-regulator involved in various cellular processes, including chromatin remodeling and gene expression. However, its role in cardiomyocytes remains largely unexplored. In this study, we investigated the global proteomic changes associ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD062686 | Pride
Trim24 Rat Neonatal rat ventricular cardiomyocytes Lc-ms/ms 
TranscriptomicsTrim24 knock down in the 2i-state of the mouse ES cells
Differentially expressed genes were determined by single-end sequencing (stranded protocol) following Trim24 and/or p53 knock down in the mouse ES cells grown in 2i media. Triplicates were generated for treatment and control samples but for p53 knock down (duplicate).
ORGANISM(S): Mus musculus 
2017-11-08 | E-MTAB-4893 | biostudies-arrayexpress
ProteomicsTRIM24 as therapeutic target in endocrine treatment resistant breast cancer
While ERα+ breast cancer treatment is considered effective, resistance to endocrine therapy is common. Since in therapy-resistance tumors, ERα is still the main driver, alternative therapeutic strategies are needed to disrupt ERα transcriptional activity. In this work, we describe TRIM24 as a key pl...
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD046736 | Pride
Erα Protac Therapy resistant breast cancer 
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