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ProteomicsiTRAQ-based proteomic analysis of style proteins and S-RNase-related proteins in Huanghua and its homozygous S-genotype offspring
We used iTRAQ technology to investigate the protein expression characteristics of S-RNases in S-gene homozygous germplasm. By using MaxQuant to search the raw mass spectrometry data files against the protein database, a total of 30,503 identified spectra, 13,568 peptides, and 4,472 proteins were ide...
ORGANISM(S): Pyrus pyrifolia 
2024-01-26 | PXD043543 | Pride
S-rnase Style Itraq Pyrus Homozygous 
TranscriptomicsGenome wide gene expression in a patient with 15q13.3 homozygous microdeletion syndrome
We identified a novel homozygous 15q13.3 microdeletion in a young boy with a complex neurodevelopmental disorder characterized by severe cerebral visual impairment with additional signs of congenital stationary night blindness (CSNB), congenital hypotonia with areflexia, profound intellectual disabi...
ORGANISM(S): Homo sapiens 
2013-02-17 | E-GEOD-43583 | biostudies-arrayexpress
TranscriptomicsWhole-genome sequencing of the CRISPR/Cas9-generated cell lines G12LS and C07 carrying a heterozygous and homozygous mutation in the RB1 gene and their parental human embryonic stem cell line H9.
Heterozygous and homozygous mutations were introduced to the human embryonic stem cell line H9 by using the CRISPR/Cas9-system. Since off-target effects can occur and high numbers of SNVs can be acquired during clonal selection, the generated cell lines and the parental cell line were analyzed by wh...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10320 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast homozygous and essential heterozygous diploid deletion strains screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded homozygous and essential heterozygous diploid deletion strains of S. cerevisiae were screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-19 | E-TABM-560 | biostudies-arrayexpress
GenomicsExpression data from wild-type and Robo2 homozygous kidneys
Expression data from wild-type and Robo2 homozygous kidneys
PRJNA565060 | ENA
TranscriptomicsMicroRNA expression profile in Dgcr8-homozygous mutant mouse embryonic stem cells
We investigated the effect of Dgcr8-homozygous mutation on microRNA expression profile in mouse embryonic stem cells. MicroRNA expression was substantially impaired, indicating a pivotal role of DGCR8 in microRNA biogenesis. MicroRNA expression profile was compared between Dgcr8-homozygous mutant ES...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-20268 | biostudies-arrayexpress
TranscriptomicsGenome expression between homozygous and heterozygous yeast wine strains
Genome expression analysis between the yeast wine strain L-846 (diploid heterozygous) and spore derived from it (diploid homozygous). Slides contained cDNA clones spotted in duplicate. A repeated dye-swap design was used.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-30 | E-GEOD-21214 | biostudies-arrayexpress
TranscriptomicsA novel unusual chromosome 11 abnormality: a homozygous somatic deletion of the entire WT1 gene within a heterozygous 11p13 deletion and UPD limited to 11p15 in a Wilms tumor and establishment of an immortalized cell line
We describe a stromal predominant Wilms tumor with a complex, tumor specific chromosome 11 aberration: a homozygous deletion of the entire WT1 gene within a heterozygous 11p13 deletion and an additional region of uniparental disomy (UPD) limited to 11p15.5-p15.2 including the IGF2 gene. The tumor ca...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-71265 | biostudies-arrayexpress
GenomicsBrain transcriptome analysis of Slc6a20a heterozygous and homozygous mutant mice
Brain transcriptome analysis of Slc6a20a heterozygous and homozygous mutant mice
PRJNA796002 | ENA
GenomicsRNA sequencing of wildtype and homozygous titin A178D mouse left ventricle samples
RNA sequencing of wildtype and homozygous titin A178D mouse left ventricle samples
PRJNA646499 | ENA
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