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TranscriptomicsTranscription profiling of human and mouse hepatocytes to perform a comparative analysis of gene regulation by the transcription factor PPARI?_mouse
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-17250 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and moise primary hepatocytes from 12 donors were treated with PPARI? agonist Wy14643
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-17254 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse PPARalpha knockouse to investigate TPPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
Background: The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called ‘intestinal barrier proteins’. An important receptor that mediates the effects of dietary lipids on g...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-9533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse small intestine following a four week diet high high in polyunsaturated fatty acids of marine origin
Dietary polyunsaturated fatty acids (PUFA) act as potent natural hypolipidemics and are linked to many health benefits in humans and in animal models. Mice fed long-term a high fat diet, in which medium-chain alpha linoleic acid (ALA) was partially replaced by long-chain docosahexaenoic (DHA) and ei...
ORGANISM(S): Mus musculus 
2009-04-16 | E-GEOD-11936 | biostudies-arrayexpress
TranscriptomicsMicrobiota facilitates dietary heme-induced epithelial hyperproliferation and hyperplasia by breaking the mucus barrier
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits epithelial damage and compensatory hyperproliferation, leading to hyperplasia. Here we explore the possible causal role of the gut microbiota in heme-...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-40670 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human primary hepatocytes treated with transcription factor PPAR agonist Wy14643
Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via anal...
ORGANISM(S): Homo sapiens 
2009-09-25 | E-GEOD-17251 | biostudies-arrayexpress
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49065 | biostudies-arrayexpress
TranscriptomicsGut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
Acetate, propionate and butyrate are the main short-chain fatty acids (SCFAs) that arise from the fermentation of fibers by the colonic microbiota. While many studies focus on the regulatory role of SCFAs, their quantitative role as a catabolic or anabolic substrate for the host has received relativ...
ORGANISM(S): Mus musculus 
2013-10-21 | E-GEOD-45926 | biostudies-arrayexpress
TranscriptomicsDietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon
This SuperSeries is composed of the following subset Series: GSE27847: Dietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon (part 1) GSE27848: Dietary heme stimulates epithelial cell turnover by downregulating feedback inhibitors of ...
ORGANISM(S): Mus musculus 
2011-10-01 | E-GEOD-27849 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peripheral blood mononuclear cells from individuals after treatment with fish oil containing EPA/DHA or high oleic acid sunflower oil
Not available
ORGANISM(S): Homo sapiens 
2009-07-07 | E-MTAB-48 | biostudies-arrayexpress
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