Physiological pathway of bone metabolism have been characterized well relatively. But antagonic pathway are less well studied. Here we investigated a negative regulator of osteogenesis with peroxiredoxin 5 (Prdx5) knockout mice that shows delay the bone metabolism. Prdx5-deficiency triggers a drasti...
Dynamic regulation of glucose flux between aerobic glycolysis and the pentose phosphate pathway (PPP) during epithelial-mesenchymal transition (EMT) is not well-understood. Here we show that Snail (SNAI1), a key transcriptional repressor of EMT, regulates glucose flux toward PPP, allowing cancer cel...
Proteogenomics is an emerging approach to improve gene annotation and interpretation of proteomics data. Here we present JUMPg, an integrative proteogenomics pipeline including customized database construction, tag-based database search, peptide-spectrum match filtering, and data visualization. JUMP...
