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ProteomicsAfrican swine fever virus protein CP204L is involved in endosomal trafficking and interacts with the VPS39 subunit of the HOPS complex
African swine fever virus (ASFV) is a large DNA virus causing a highly contagious disease in domestic and wild boar, for which no treatment is available. ASFV vaccine development is hindered by large gaps in knowledge considering virus protein function and virus-host interaction. This study shows th...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-01-23 | PXD035695 | Pride
Cp204l Hops complex Asfv Vps39 Virus-host ppi 
ProteomicsSNAP47 acetylation-dependent regulatory mechanism governing autophagosome-lysosome fusion by modulating the recruitment of HOPS to autophagic vacuoles
Autophagy, a conserved catabolic process implicated in a diverse array of human diseases, requires efficient fusion between autophagosomes and lysosomes to function effectively. Recently, SNAP47 has been identified as a key component of the default SNARE complex mediating autophagosome-lysosome fusi...
ORGANISM(S): Homo Sapiens 
2024-05-13 | PXD052239 |
ProteomicsXanthohumol Activity-Based Probes Targeting Flavonoid Catabolism
Xanthohumol, the principle prenylflavonoid found in hops (Humulus lupulus), is a potential anti-inflammatory agent in the gut. To investigate the interactions between xanthohumol and catabolic gut bacteria, and its role in the anti-inflammatory pathway, a suite of xanthohumol-derived activity-based ...
ORGANISM(S): Eubacterium Ramulus (ncbitaxon:39490) Escherichia Coli (ncbitaxon:562) 
2022-02-04 | MSV000088789 | MassIVE
UnknownRILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking.
Not available
S-EPMC4250914 | biostudies-literature
UnknownStructural basis of Vps33A recruitment to the human HOPS complex by Vps16.
Not available
S-EPMC3746937 | biostudies-literature
UnknownHOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assembly.
Not available
S-EPMC2893992 | biostudies-literature
UnknownStructure of the HOPS tethering complex, a lysosomal membrane fusion machinery.
Not available
S-EPMC9592082 | biostudies-literature
UnknownHOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.
Not available
S-EPMC5385945 | biostudies-literature
UnknownThe small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.
Not available
S-EPMC4432227 | biostudies-literature
UnknownPurification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.
Not available
S-EPMC1440844 | biostudies-literature
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