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TranscriptomicsExpression data of skeletal muscle from HRT users and non-users
Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Even though menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or men...
ORGANISM(S): Homo sapiens 
2007-11-12 | E-GEOD-6348 | biostudies-arrayexpress
TranscriptomicsMicroRNA sequencing of human serum exosomes from women with different age and hormonal status
This study investigated differences in serum exosome microRNA-cargo, obtained from healthy postmenopausal monozygotic twins (n=10 pairs), from which the other sister was using estrogen-based hormone replacement therapy (HRT) and the other was not under treatment. In addition, premenopausal women (n=...
ORGANISM(S): Homo sapiens 
2017-02-14 | E-MTAB-5245 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the effects of Power Training and Hormone Replacement Therapy on muscle properties
Muscle mass and strength reduce during ageing with a steeper decline in women around the age of 50, which suggests that the menopausal transition is one of the mechanisms for age-induced neuromuscular deteriorations. At the moment, there is no clear explanation for the decline in muscle properties a...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-GEOD-16907 | biostudies-arrayexpress
TranscriptomicsAorta- and liver-specific ERalpha binding patterns and gene regulation by estrogen
Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of venous thromboses linked to upregulation of coagulation factors in the liver. In mouse models, the ...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-57804 | biostudies-arrayexpress
ProteomicsProteomic analysis of skeletal muscle reveals estrogen as a key regulator of muscle signaling in women
Women’s aging is characterized by menopausal loss of ovarian function, which has been suggested as a contributing factor to aging-related muscle deterioration and predisposes to the metabolic dysfunctions. However, the underlying molecular mechanisms have remained unknown. To identify mechanisms, we...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD006446 | Pride
Human Estrogen Hdmse Aging Muscle Hormon replacement therapy 
TranscriptomicsGlobal gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy
Analysis of gene expression profiles in skeletal muscle tissue after long-term use of HRT. Networks of enriched processes in skeletal muscle responding to long-term use of estrogen-based HRT in comparison with women without any HRT in a genetically controlled setting were contructed. The association...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-21421 | biostudies-arrayexpress
TranscriptomicsTissue Specific Pathways for Estrogen Regulation of Ovarian Cancer Growth and Metastasis
Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed pre-existing disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperito...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-22600 | biostudies-arrayexpress
TranscriptomicsMolecular Analysis of the Vaginal Response to Estrogens in the Ovariectomized Rat and Postmenopausal Woman
Background. Vaginal atrophy (VA) is the thinning of the vaginal epithelial lining, typically the result of lowered estrogen levels during menopause. Some of the consequences of VA include increased susceptibility to bacterial infection, pain during sexual intercourse, and vaginal burning or itching....
ORGANISM(S): Rattus norvegicus 
2009-05-20 | E-GEOD-11622 | biostudies-arrayexpress
TranscriptomicsAn Association Between Gene Expression and Better Survival in Female Mice Following Myocardial Infarction
Following myocardial infarction, the prognosis for females is better than males. Estrogen is thought to be protective, but clinical trials with hormone replacement failed to show protection. Here, we sought to identify novel mechanisms that might explain this sex-based difference. By diverging from ...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-23294 | biostudies-arrayexpress
MetabolomicsExploring the effect of estrogen on Candida albicans hyphal cell wall glycans and ergosterol synthesis
Increased levels of 17-β estradiol (E2) due to pregnancy in young women or to hormonal replacement therapy in postmenopausal women have long been associated with an increased risk of yeast infections. Nevertheless, the effect underlying the role of E2 in Candida albicans infections is not wel...
2025-09-11 | MTBLS5821 | MetaboLights
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