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GenomicsGenome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
The estrogen receptor alpha (ERa) drives the growth of two-thirds of all breast cancers. Endocrine therapy impinges on estrogen-induced ERa activation to block tumor growth. However, half of ERa-positive breast cancers are tolerant or acquire endocrine therapy resistance. Here we demonstrate that br...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-37323 | biostudies-arrayexpress
TranscriptomicsExpression profile of the endocrine therapy resistant breast cancer cells LTED depleted of PBX1 or treated with the gamma-secretase inhibitor MRK003
Analysis of the response to PBX1 deprivation either using an siRNA approach or using a chemicalcompound indirectly targeting it. Deprivation of PBX1 is hypothesized to be essential for the growth of endocrine therapy resistant breast cancer cells (LTED) Total RNA was obtained from cells treated with...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-36928 | biostudies-arrayexpress
TranscriptomicsExpression data of skeletal muscle from HRT users and non-users
Modification of Gene Expression of Skeletal Muscle in Response to postmenopause with or without Hormone Replacement Therapy. Even though menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or men...
ORGANISM(S): Homo sapiens 
2007-11-12 | E-GEOD-6348 | biostudies-arrayexpress
ProteomicsProteomic analysis of skeletal muscle reveals estrogen as a key regulator of muscle signaling in women
Women’s aging is characterized by menopausal loss of ovarian function, which has been suggested as a contributing factor to aging-related muscle deterioration and predisposes to the metabolic dysfunctions. However, the underlying molecular mechanisms have remained unknown. To identify mechanisms, we...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD006446 | Pride
Human Estrogen Hdmse Aging Muscle Hormon replacement therapy 
TranscriptomicsMicroRNA sequencing of human serum exosomes from women with different age and hormonal status
This study investigated differences in serum exosome microRNA-cargo, obtained from healthy postmenopausal monozygotic twins (n=10 pairs), from which the other sister was using estrogen-based hormone replacement therapy (HRT) and the other was not under treatment. In addition, premenopausal women (n=...
ORGANISM(S): Homo sapiens 
2017-02-14 | E-MTAB-5245 | biostudies-arrayexpress
TranscriptomicsExpression profile of the endocrine therapy sensitive breast cancer cells MCF7 depleted of PBX1
Effect of PBX1 silencing on global gene expression of MCF7 cells stimulated with EGF. The hypothesis tested was that PBX1 is essential for EGF signaling in ERa positive breast cancer cells. Total RNA was obtained from MCF7 cells treated with siRNA directed at PBX1 or an siControl for 72h. Cells were...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39417 | biostudies-arrayexpress
TranscriptomicsGenome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-39418 | biostudies-arrayexpress
ProteomicsFunctional and omics-based rationale for the induction of BRCAness by androgen receptor pathway inhibitors to sensitize prostate cancer to PARP inhibition, regardless of HRR status
Two PARP inhibitors (PARPi) olaparib and talazoparib have been approved in combination with novel-hormonal-therapies (NHTs) for the treatment of metastatic castration resistant prostate cancer (mCRPC) – in Europe independent of the HRR status. However, the underlying mechanism of action in HRR negat...
ORGANISM(S): Homo sapiens (Human) 
2026-07-10 | PXD063764 | Pride
Hormon therapy Organoids Proteomics Prostate cancer 
ProteomicsCoordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance
Phenotypic plasticity has emerged as an important mechanism of therapy resistance in cancers, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model for endocrine resistance, we show that hormone resistance is associated with enhanced phenotypic pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-24 | MSV000083857 | MassIVE
TranscriptomicsTissue Specific Pathways for Estrogen Regulation of Ovarian Cancer Growth and Metastasis
Menopausal estrogen (E2) replacement therapy increases the risk of estrogen receptor (ER)-positive epithelial ovarian cancers (EOC). Whether E2 is tumorigenic or promotes expansion of undiagnosed pre-existing disease is unknown. To determine E2 effects on tumor promotion, we developed an intraperito...
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-22600 | biostudies-arrayexpress
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