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MetabolomicsSerum metabolomic profiles associated with postmenopausal hormone use

INTRODUCTION: Postmenopausal hormone use is linked to several health outcomes and the risk associated with some may differ depending on whether estrogen is used alone or in combination with progestin.

OBJECTIVE: Metabolomic analyses of postmenopausal hormon...

2019-06-02 | MTBLS136 | MetaboLights
MetabolomicsImpact of in vitro hormone treatments on the bibenzyl production of Radula complanata (Untargeted metabolomics)

Bibenzyls are a specialized metabolite class found throughout the plant kingdom. One of the most prolific producers of bibenzyls are liverworts, specifically plants of the Radula genera. These plants possess an incredible diversity of bibenzyls, prenylated bibenzyls and a few (bis)bibenz...

2024-01-10 | MTBLS3563 | MetaboLights
MetabolomicsImpact of in vitro hormone treatments on the bibenzyl production of Radula complanata (Targeted metabolomics)

Bibenzyls are a specialized metabolite class found throughout the plant kingdom. One of the most prolific producers of bibenzyls are liverworts, specifically plants of the Radula genera. These plants possess an incredible diversity of bibenzyls, prenylated bibenzyls and a few (bis)bibenz...

2024-01-10 | MTBLS4321 | MetaboLights
MetabolomicsOxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell line...
2023-06-27 | MTBLS3342 | MetaboLights
MetabolomicsDysregulation of the 3β-Hydroxysteroid Dehydrogenase Type 2 Enzyme and Steroid Hormone Biosynthesis in Chronic Kidney Disease

Chronic kidney disease (CKD) presents a critical global health challenge, marked by the progressive decline of renal function. This study explores the role of the 3β-hydroxysteroid dehydrogenase type 2 enzyme (HSD3B2) and steroid hormone biosynthesis pathway in CKD pathogenesis and progression. U...

2024-10-10 | MTBLS10715 | MetaboLights
MetabolomicsExploring Lipidomic Profiles and Their Correlation with Hormone Receptor and HER2 Status in Breast Cancer
Dysregulated lipid metabolism promotes the progression of various cancers, including breast cancer. This study aimed to explore the lipidomic profiles of breast cancer patients, providing insights into the correlation between lipid compositions and tumor subtypes characterized by hormone receptor (H...
2024-08-16 | MTBLS10858 | MetaboLights
TranscriptomicsTranscription profiling of whole blood from women exposed to hormone replacement therapy and those with no treatment
The American Women's Health Initiative study published in July 2002 caused considerable concern among hormone replacement therapy (HRT) users and prescribers in many countries. This study is an exploratory research comparing the genome wide expression profile in whole blood samples according to HRT ...
ORGANISM(S): Homo sapiens 
2007-11-28 | E-GEOD-3492 | biostudies-arrayexpress
MetabolomicsProteomic analysis validates previous findings on wounding-responsive plant hormone signaling and primary metabolism contributing to the biosynthesis of secondary metabolites based on metabolomic analysis in harvested broccoli (Brassica oleracea L. var. italica)
The plant wound-response is a complex process that generates physiological modifications for protecting the wounded tissue. In this study, tandem mass tag (TMT)-based quantitative proteomic analysis was performed to clarify the comprehensive molecular mechanism for the wound-response of broccoli subj...
2021-05-19 | MTBLS2317 | MetaboLights
TranscriptomicsExpression data from healthy postmenopausal women on 4 different types of hormone therapy, the RET study
Postmenopausal hormone therapy (HT) is associated with many diseases and conditions, but the underlying molecular mechanisms involved are incompletely understood. The aim of the current study was to investigate the effect of 4 types of HT on gene transcription. 24 women (6 women in 4 treatment group...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-24859 | biostudies-arrayexpress
TranscriptomicsInhibitory Actions of Anti-MM-CM-
The current study was designed to investigate the actions of Anti-MM-CM-
ORGANISM(S): Rattus norvegicus 
2011-03-04 | E-GEOD-25629 | biostudies-arrayexpress
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