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TranscriptomicsGlucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations with Aging
Although glucocorticoids (GCs) are known to exert numerous effects in the hippocampus, their chronic regulatory functions remain poorly understood. Moreover, evidence is inconsistent regarding the longstanding hypothesis that chronic GC exposure promotes brain aging/Alzheimer's disease. Here, we adr...
ORGANISM(S): Rattus norvegicus 
2013-07-22 | E-GEOD-37618 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse hippocampus under ibotenic acid treatment.
Mice (n=85) were anaesthetised by ip injection (0.1 ml/10 g) of xylazine (5%) and ketamine (10%) diluted in sterile water. After placing animals in a stereotactic frame, the skull surface was exposed and holes were drilled at the appropriate sites to allow bilateral infusion of ibotenic acid (10 ï¾µ...
ORGANISM(S): Mus musculus 
2011-03-31 | E-MEXP-2682 | biostudies-arrayexpress
TranscriptomicsComparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2) on gene expression in bovine endometrium
Interferon tau (IFNT), a Type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal, produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression changes during early pregnancy were compared to ...
ORGANISM(S): Bos taurus 
2011-10-31 | E-GEOD-30694 | biostudies-arrayexpress
TranscriptomicsCombined effects of ZnO and TiO2 nanoparticles on functional gene expression of Nitrosomonas europaea
To further explore and differentiate the biotoxicity mechanisms of individual nanoparticles (NPs) and NP mixture on Nitrosomonas europaea (N. europaea, ATCC 19718) at genetic level, a genome-sequenced model ammonia oxidizing bacterium (AOB) commonly detected in the activated sludge of biological was...
ORGANISM(S): Nitrosomonas europaea ATCC 19718 
2015-06-23 | E-GEOD-70121 | biostudies-arrayexpress
TranscriptomicsFunctional gene expressions of continuously cultured Nitrosomonas europae after ZnO nanoparticles exposure and recovery incubation
To further explore the biotoxicity mechanisms of zinc oxide nanoparticles (ZnO NPs) and the recovery strategies of the accordingly impaired Nitrosomonas europaea (N. europaea, ATCC 19718) cells, a genome-sequenced model ammonia-oxidizing bacterium (AOB) commonly detected in the activated sludge of b...
ORGANISM(S): Nitrosomonas europaea ATCC 19718 
2016-06-24 | E-GEOD-83683 | biostudies-arrayexpress
TranscriptomicsIDH1 mutation defines methylation class and survival in human glioma
Astrocytoma, oligodendroglioma, oligoastrocytoma, and ependymoma are the main histologic subtypes of glioma. The molecular character of these subtypes has profound implications for understanding their causes and treatment. We describe the epigenetic landscape of these tumor types using novel DNA met...
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-20395 | biostudies-arrayexpress
MetabolomicsEffects of a Compound from the Group of Substituted Thiadiazines with Hypothermia Inducing Properties on Brain Metabolism in Rats, a Study In Vivo and In Vitro
The aim of the present study was to examine how administration of a compound of 1,3,4-thiadiazine class 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (L-17) with hypothermia inducing properties affects the brain metabolism. The mechanism by which L-17 induces hypothermia is unknown; it may...
2018-07-27 | MTBLS482 | MetaboLights
TranscriptomicsTranscription profiling of primary hippocampal neurons isolated from mouse E17 embryos and undergoing differentiation in the culture for 7h, 18h, 33h, 72h, 8 days, 12 days (at which time points the RNA was extracted) vs RNA isolated from a newborn brain
A time-course experiment, in which the gene expression in the primary hippocampal neurons isolated from E17 embryos and undergoing differentiation in the culture for 7h, 18h, 33h, 72h, 8 days, 12 days (at which time points the RNA was extracted) was compared by competitive hybridization with a commo...
ORGANISM(S): Mus musculus 
2003-06-01 | E-MEXP-11 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetus
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of 3rd trimester pregnant pigs can result in transmission of the virus to the fetus and ultimately death in utero or postnatally. Little is known about the immune response to infection at the maternal-fetal interface and in the fe...
ORGANISM(S): Sus scrofa 
2016-05-17 | E-GEOD-71205 | biostudies-arrayexpress
TranscriptomicsAnalyzing the hippocampal gene network to determine the effects of coral calcium hydride on antioxidant ability in rat brain
In our previous study, we reported that a diet rich in antioxidants such as coral calcium hydride (CCH) increased the endogenous antioxidant ability in the hippocampus of rats. We conducted this study to test the hypothesis that diet supplementation with CCH would change the gene expression in rats ...
ORGANISM(S): Rattus norvegicus 
2013-12-31 | E-GEOD-48623 | biostudies-arrayexpress
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