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TranscriptomicsEvidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau
The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of...
ORGANISM(S): Bos taurus 
2014-04-01 | E-GEOD-56392 | biostudies-arrayexpress
TranscriptomicsConserved epigenetic sensitivity to early life experience in the rat and human hippocampus
Early life experience is associated with long-term effects on behavior and epigenetic programming of the NR3C1 (glucocorticoid receptor) gene in the hippocampus of both rats and humans. However, it is unlikely that such effects completely capture the evolutionarily conserved epigenetic mechanisms of...
ORGANISM(S): Homo sapiens 
2012-05-30 | E-GEOD-38352 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stromal cells to reveal senescence associated gene expression changes
Transcription profiling of human mesenchymal cells (MSCs) after ex vivo expansion under culture conditions supporting extensive cell proliferation. Highly efficient cell expansion within short time (~40 days) and comparison of gene expression profiles from MSCs after primary seeding, defined as earl...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MEXP-1997 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mesenchymal stem cells to determine changes over the course of cellular aging
To determine gene expression changes during in vitro senescence of MSC we have analyzed differential expression of the corresponding early passage (P2) and senescent passage (PX). There were global changes in the gene expression profile that were reproducible in three independent donor samples. Expe...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9593 | biostudies-arrayexpress
TranscriptomicsSexually dimorphic gene expression in bovine conceptuses at the initiation of implantation is not reflected in the changes in the endometrial transcriptome.
In cattle, maternal recognition of pregnancy occurs on Day 16 via secretion of interferon tau (IFNT) by the conceptus. The endometrium can distinguish between embryos with different developmental competencies. In eutherian mammals, X-chromosome inactivation (XCI) is required to ensure an equal trans...
ORGANISM(S): Bos taurus 
2016-03-01 | E-GEOD-75754 | biostudies-arrayexpress
TranscriptomicsBroad epigenetic signature of maternal care in the brain of adult rats (expression)
Maternal care is associated with long-term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans. However, epigenetic changes at a single gene promoter are unlikely to account for the range of responses to the early life...
ORGANISM(S): Rattus norvegicus 
2011-03-09 | E-GEOD-20717 | biostudies-arrayexpress
TranscriptomicsBroad epigenetic signature of maternal care in the brain of adult rats (DNA methylation and H3K9 acetylation profiles)
Maternal care is associated with long-term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans. However, epigenetic changes at a single gene promoter are unlikely to account for the range of responses to the early life...
ORGANISM(S): Rattus norvegicus 
2011-03-09 | E-GEOD-20714 | biostudies-arrayexpress
TranscriptomicsOntogenetic study of gene expression in human cerebral cortex tissue using genome-wide microarray
In this study we sought to examine gene expression in the cerebral cortex during development in the context of adaptive plasticity. In order to do this we introduced an approach designed to discriminate genes with variable as opposed to uniform patterns of gene expression and found that greater inte...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37721 | biostudies-arrayexpress
UnknownContinued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: The SURMOUNT-4 Randomized Clinical Trial.
Not available
S-EPMC10714284 | biostudies-literature
ProteomicsHigh-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Glioblastoma, the most aggressive primary brain cancer, has dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities of glioblastoma. To this end, we here syste...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090357 | MassIVE
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