Sort   by:  
 Page size 
TranscriptomicsMFAP4 is an integrin M-NM-1VM-NM-23/5 ligand involved in vascular remodeling
Arterial injury or occlusive arterial disease may stimulate healing responses, which when overexuberant, leads to restenosis of the injured vessel. This response is influenced by specific integrin signalling in vascular smooth muscle cells (VSMCs). Microfibril-associated protein 4 (MFAP4) colocates ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-40480 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Dll1 mutant mouse lines on different genetic background
The evolutionarily conserved Delta-Notch cell-cell signal-transduction pathway regulates the determination of various cell fates, which are important for the morphogenesis and development of numerous organs and tissues in many vertebrates and invertebrates. The Dll1 gene was mutated by homologous r...
ORGANISM(S): Mus musculus 
2009-01-01 | E-GEOD-11867 | biostudies-arrayexpress
TranscriptomicsLoss of the actin remodeler Eps8 causes calorie restriction and improved metabolic status in mice
In a variety of organisms, including mammals, caloric restriction improves metabolic status and lowers the incidence of chronic-degenerative diseases, ultimately leading to increased lifespan. Here we show that knockout mice for Eps8, a regulator of actin dynamics, display reduced bodyweight, partia...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-14454 | biostudies-arrayexpress
TranscriptomicsIdentification and validation of novel ERBB2 (HER2, NEU) targets including genes
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (ERBB2; synonyms HER2, NEU) encodes a transmembrane glycoprotein with tyrosine kinase-specific activity that acts as a major switch in different signal-transduction processes. ERBB2 amplification and overexpression have been found in a number...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-16445 | biostudies-arrayexpress
TranscriptomicsMultiple functions for Eya3 in mammalian organism
The important function of Eya (eyes absent) in eye development of D.melanogaster is well known, the function of its mammalian orthologs Eya1-4 is only partially understood. Yet, no phenotype for Eya2 and Eya3 in humans or mouse have been described. In our study we analysed new Eya-deficient mouse m...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-9999 | biostudies-arrayexpress
TranscriptomicsGene regulation in ki-ras transfected murine fibroblasts
Ki-ras gene mutations are involved in the carcinogenesis of acute myeloid leukemia, melanoma and different carcinomas. In order to define potential mutation-specific therapeutic targets, expression profiling analyses were performed using stable transfected NIH3T3 cells carrying different ki-ras gene...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8372 | biostudies-arrayexpress
TranscriptomicsGene regulation in brain, eye and heart of sighted C3H mice
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the...
ORGANISM(S): Mus musculus 
2010-05-23 | E-GEOD-7855 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of Dll1 mutant mouse line
BACKGROUND: The Notch signaling pathway is an evolutionary conserved signal transduction pathway involved in embryonic patterning and regulation of cell fates during development and self-renewal. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, invo...
ORGANISM(S): Mus musculus 
2009-03-01 | E-GEOD-12954 | biostudies-arrayexpress
TranscriptomicsGene expression profile of a murin neuroblastoma cell line infected with the prion strain 22L
The underlying pathogenic mechanisms of prion infection are not well characterized. To study the effect of prion infection on gene expression in neuronal cell cultures, a neuroblastoma (N2a) cell clone was infected with either the mouse adapted prion strain 22L or exposed to uninfected brain homogen...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-7119 | biostudies-arrayexpress
TranscriptomicsGene regulation in Erbb2 transfected NIH3T3 cells after Azacytidine treatment
5-Azacytidine or 5-aza-2â??-deoxycytidine is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Cells in the presence of 5-azacytidine incorporate it into DNA during replication and RNA during transcription. The incorporation of 5-azacytidine into DNA or RNA inhibits methyltransfera...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-8374 | biostudies-arrayexpress
Sort   by:  
 Page size