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TranscriptomicsmRNA profile of 5-aza-CR and 5-aza-CdR treated celllines
5-azacytidine and 5-aza-2'-deoxycytidine are both demethylating agents but they have shown different clinical efficiency. Since 5-azacytidine is incorporated into RNA it might have a different impact on the expression profile than 5-aza-2'-deoxycytidine. This study is designed to investigate the imm...
ORGANISM(S): Homo sapiens 
2014-06-13 | E-MTAB-280 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of human myeloid and urinary bladder carcinoma cell lines treated with 5-Azacytidine or 5-aza-2-deoxycytidine
Not available
ORGANISM(S): Homo sapiens 
2010-09-08 | E-MTAB-279 | biostudies-arrayexpress
TranscriptomicsDevelopment and blind clinical validation of a microRNA based predictor of response to treatment with R-CHOEP in DLBCL
microRNAs er are group of short noncoding RNAs that regulate gene expression at the posttranslational level. It has been shown that mirs are independent predictios of outcome in patients with diffuse large b cell lymphoma treated with r-chop. Outcome in patients with dlbcl lymphoma treated with r-ch...
ORGANISM(S): Homo sapiens 
2015-02-20 | E-GEOD-40239 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of TET2 wild type and TET2 mutant patients with diffuse large B-cell derived lymphoma
Global gene expression in TET2 mutant and Wild type patients. We performed an integrated analysis of global DNA methylation and gene expression data to investigate the effects of DNA hypermethylation on gene expression. Total RNA was isolated from 4 TET2mut and 5 TET2wt were isolated using standard...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-37363 | biostudies-arrayexpress
TranscriptomicsTET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma (DNA methylation)
Genome wide DNA methylation profiling of patient samples with TET2 mutations and Wild type TET2 status . The Illumina Infinium HumanMethylation 450_15017482_v.1.1 was used to obtain DNA methylation profiles across approximately 482,421 CpGs in fresh frozen lymphoma samples. Samples include 19 TET2...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-37362 | biostudies-arrayexpress
TranscriptomicsHuman bone marrow precursor cells
The aim of this study was to characterize in vivo miRNA expression in normal myeloid development of the neutrophil granulocyte (granulopoiesis) to gain insight into miRNA control of these processes. Cell populations highly enriched in precursors from successive stages of granulopoiesis and mature ne...
ORGANISM(S): Homo sapiens 
2011-10-21 | E-GEOD-33140 | biostudies-arrayexpress
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