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UnknownIdentification of a novel WAS mutation and the non-splicing effect of a second-site mutation in a Chinese pedigree with Wiskott-Aldrich syndrome.

Background

Wiskott-Aldrich syndrome (WAS) is a rare X-linked immunodeficiency disorder caused by abnormal expression of the WAS protein (WASp) due to mutations in the WAS gene, and is generally characterized by microthrombocytopenia, eczema, recurrent infections, and high susceptibility to a...
S-EPMC9783790 | biostudies-literature
ProteomicsCharacterization, Antioxidant Effects of Lycium ruthenicum Murr. Polysaccharides and its Protective Effects Against Oxaliplatin-Induced Peripheral Neurotoxicity by Inhibiting the RAS-RAF-MEK-ERK Signaling Pathway
Oxaliplatin is a frequently used chemotherapeutic agent; however, oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent adverse effect for which no effective treatment currently exists. Lycium ruthenicum Murr. (LR), a traditional Chinese medicinal herb also consumed as food, is rich in pol...
ORGANISM(S): Rattus Norvegicus 
2025-11-26 | PXD071288 |
UnknownA New Criterion for Pediatric AKI Based on the Reference Change Value of Serum Creatinine.

Background

Current definitions of AKI do not take into account serum creatinine's high variability in children.

Methods

We analyzed data from 156,075 hospitalized children with at least two creatinine tests within 30 days. We estimated reference change value (RCV) of creatinine on the...
S-EPMC6115652 | biostudies-literature
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