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ProteomicsAgonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome
Natural compounds that can stimulate salivary secretion are of interest in developing treatments for xerostomia, the perception of a dry mouth, that affects between 10 and 30% of the adult and elderly population. Chemesthetic transient receptor potential (TRP) channels are expressed in the surface ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-16 | PXD017232 | Pride
Menthol Proteome Transient receptor potential channel agonists Nonivamide Saliva Cinnamaldehyde 
ProteomicsThe homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion
Cell-cell communication in multicellular organisms depends on the dynamic and reversible phosphorylation of protein tyrosine residues. The receptor-linked protein tyrosine phosphatases (RPTPs) receive cues from the extracellular environment and are well placed to influence cell signaling. However, t...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013055 | Pride
Phosphorylation  silac 
UnknownComparing the Efficacy and Safety of Nemolizumab Versus Anti-interleukin Monoclonal Antibody Therapies in Combination with Topical Treatments for Moderate-to-Severe Atopic Dermatitis Using Network Meta-analysis.
Not available
S-EPMC12936256 | biostudies-literature
UnknownActive Trachoma Cases in the Solomon Islands Have Varied Polymicrobial Community Structures but Do Not Associate with Individual Non-Chlamydial Pathogens of the Eye.
Not available
S-EPMC5787070 | biostudies-literature
Unknown20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years.
Not available
S-EPMC5734609 | biostudies-literature
UnknownAn Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts.
Not available
S-EPMC8225586 | biostudies-literature
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
UnknownSeverity dependent distribution of impairments in PSP and CBS: Interactive visualizations.
Not available
S-EPMC6399076 | biostudies-literature
UnknownBrain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy.
Not available
S-EPMC12553996 | biostudies-literature
UnknownBrain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy.
Not available
S-EPMC12661634 | biostudies-literature
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