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To elucidate the PP6-upregulation mechanism of L-menthol, we took advantage of an unbiased target identification approach, DARTS, to identify the target of L-menthol in keratinocytes.
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037335 | Pride
Menthol, a naturally occurring cooling compound of peppermint oil, induces an anti-proliferative activity in androgen-independent prostate cancer (AIPC). Previously, we found that menthol affects PC-3 cells viability through activating JNK but the mechanism is not fully clear. We thus studied that d...
ORGANISM(S): Homo sapiens 
Because HES1 maintained PP6 protein level without affecting its mRNA level, we asked if HES1 directly interacted with PP6 in keratinocytes.
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037336 | Pride
Thermosensitive TRP ion channels enable somatosensory nerve fibers to detect changes in our thermal environment over a wide physiologic range. In mammals, the menthol receptor, TRPM8, is activated by temperatures below ~26ºC and is essential for the perception of cold or chemical cooling agents. A f...
ORGANISM(S): Homo sapiens (Human) Pagrus major 
2026-03-25 | PXD064468 | Pride
Menthol, a naturally occurring cooling compound of peppermint oil, induces an anti-proliferative activity in androgen-independent prostate cancer (AIPC). Previously, we found that menthol affects PC-3 cells viability through activating JNK but the mechanism is not fully clear. We thus studied that d...
ORGANISM(S): Homo sapiens 
2011-08-31 | GSE28241 | GEO
To characterize the effect of menthol on macrophages, comprehensive microarray analysis was performed in RAW 264.7 macrophage.
ORGANISM(S): Mus musculus 
2018-07-31 | GSE98933 | GEO
The change of transcriptome and related biological functions affected by tobacco smoke and Electronic-cigarette (E-cig) to human gingival mesenchymal (GMSC) and periodontal ligament stem cells (PDLSCs) are not fully understood. Here, we collected GMSCs and PDLSCs from systemically healthy patients d...
ORGANISM(S): Homo sapiens 
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