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UnknownA fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages.
Not available
S-EPMC10622513 | biostudies-literature
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
TranscriptomicsTranscriptional response of Drosophila cells to FHV infection (infection experiment)
Virus infections induce cellular gene up and down regulation, and these changes often provide clues to cellular pathways utilized by viruses. We used microarrays to examine the transcriptional responses of cultured Drosophila S2 cells to infection with Flock House virus (FHV). Experiment Overall Des...
ORGANISM(S): Drosophila melanogaster 
2009-04-11 | E-GEOD-15466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila cells to FHV RNA1 replicon expression (replicon experiment)
Virus infections induce cellular gene up and down regulation, and these changes often provide clues to cellular pathways utilized by viruses. We used microarrays to examine the transcriptional responses of cultured Drosophila S2 cells to Flock House virus (FHV) replicon induction. Experiment Overall...
ORGANISM(S): Drosophila melanogaster 
2009-04-11 | E-GEOD-15467 | biostudies-arrayexpress
TranscriptomicsRNA-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci
Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products....
ORGANISM(S): Mus musculus 
2014-04-28 | E-GEOD-54952 | biostudies-arrayexpress
TranscriptomicsStrain-dependent Dissociation of Airway Hyper-responsiveness from Inflammation in a House Dust Mite Model of Asthma
Gene expression analysis of Der p 1-treated mouse lungs. We developed a new mouse model of allergic airway disease employing the house dust mite allergen Der p 1. This model produces qualitatively and quantitatively different effects in two commonly used inbred strains of mice, C57BL/6J and BALB/c...
ORGANISM(S): Mus musculus 
2010-11-30 | E-GEOD-19223 | biostudies-arrayexpress
GenomicsChIP-seq: Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci
Hox genes are essential regulators of embryonic development. They are activated in a temporal sequence following their topological order within their genomic clusters. Subsequently, states of activity are fine-tuned and maintained to translate into domains of progressively overlapping gene products....
ORGANISM(S): Mus musculus 
2014-04-28 | E-GEOD-54955 | biostudies-arrayexpress
ProteomicsPrenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities
The bactericidal function of neutrophils are dependent on myriad intrinsic and extrinsic stimuli. Using systems immunology approaches we identified microbiome- and infection-induced changes in neutrophils. We focused on investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function. Muri...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-14 | PXD031115 | Pride
Neutrophil Prenylation Pcyox1l 
TranscriptomicsReal-time quantitative PCR analysis of spleen cells
TGF-M-NM-21 signaling pathway of spleen of the Gata1low mouse model of myelofibrosis Four condition experiment. Biological replicates: 3 control CD1 mice, 3 Gata1low mice, 3 SB431542-treated Gata1low mice and 3 Vehicle-treated Gata1low mice.
ORGANISM(S): Mus musculus 
2013-03-02 | E-GEOD-44795 | biostudies-arrayexpress
GenomicsThe In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J gene segments, has not previously been characterized in vivo. Here we demonstrate that RAG protein binding occurs in a highly focal manner to a small reg...
ORGANISM(S): Mus musculus 
2010-04-19 | E-GEOD-21207 | biostudies-arrayexpress
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