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TranscriptomicsNeutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice
Neutrophil abscess formation is critical in innate immunity against many pathogens. Here, the mechanism of neutrophil abscess formation was investigated using a mouse model of Staphylococcus aureus cutaneous infection. Gene expression analysis of S. aureus-infected skin revealed that induction of ne...
ORGANISM(S): Mus musculus 
2012-12-05 | E-GEOD-36826 | biostudies-arrayexpress
TranscriptomicsCircadian liver_wt and Clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-3748 | biostudies-arrayexpress
TranscriptomicsRNA profiling in mouse haemopoiesis
RNA profiling of mouse haemopoetic lineages RNA profiling of mouse haemopoetic lineages. For the isolation and sequencing of ouse granulocyte nuclei, bone marrow from C57BL/6J was harvested from the femur, tibia and spine using a mortar and pestle in PBS supplemented with 2% (v/v) FCS and mature gra...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-20683 | biostudies-arrayexpress
Genomicsde novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation
Cytosine methylation is an epigenetic mark usually associated with gene repression. Despite a requirement for de novo DNA methylation for differentiation of embryonic stem cells, its role in somatic stem cells is unknown. Using conditional ablation, we show that loss of either, or both, Dnmt3a or Dn...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-27322 | biostudies-arrayexpress
TranscriptomicsComparison of Invasive TAM sub-population to General TAM population
The tumor microenvironment modifies the malignancy of tumors. In solid tumors this environment is populated by many macrophages (tumor-associated macrophages; TAMs) that in genetic studies that depleted these cells from mouse models of breast cancer were shown to promote tumor progression to maligna...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-18295 | biostudies-arrayexpress
TranscriptomicsCircadian rhythm in clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-3751 | biostudies-arrayexpress
TranscriptomicsCircadian skeletal muscle_wt and Clock mutants
One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into ...
ORGANISM(S): Mus musculus 
2010-06-11 | E-GEOD-3746 | biostudies-arrayexpress
UnknownNeuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study.
Not available
S-EPMC5133666 | biostudies-literature
ProteomicsCharacterization of the NTSR1-Arr2 complex
An in vitro prepared NTSR1-Arr2 complex was stabilized by use of heterobifunctional crosslinker. Here we characterize the crosslinks observed upon photo-illumination of this complex.
ORGANISM(S): Homo sapiens (Human) 
2019-12-19 | PXD016224 | Pride
Arresin Gpcr Crosslinking 
TranscriptomicsGene expression changes in feeding female and male lone star ticks, Amblyomma americanum (L)
A collection of 1145 clones from an EST project on female tick salivary gland genes was hybridized on glass slides to RNA extracted from several feeding stages of adult female tick salivary glands, including unfed and replete, and from adult male ticks, either unfed or fed in the presence or absence...
ORGANISM(S): Amblyomma americanum 
2010-06-11 | E-GEOD-5010 | biostudies-arrayexpress
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