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Membrane glycoproteins often adopt different conformations when shifting between active and inactive states. Here, we discover a molecular switch that operates through major changes in the spatial arrangement of the N-glycan landscape during such conformational transitions. We demonstrate that the c...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2025-11-10 | PXD041522 | Pride
Myocardial ischemia-reperfusion injury (MIRI) is a major threat to heart functional integrity and pharmacological means to achieve cardioprotection are sorely needed. The sequential hypoxic/normoxic status of the cardiac tissue triggers life-threatening damages through the activation of multiple int...
ORGANISM(S): Homo sapiens (Human) 
2022-09-13 | PXD036607 | Pride
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