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ProteomicsMetabolic Reprogramming Driven by Ant2 Deficiency Augments T Cell Function and Anti-Tumor Immunity
cell activation demands a significant boost in NAD+ levels, often outpacing the capacity of oxidative phosphorylation (OXPHOS). To explore how T cells manage this metabolic stress, we created T cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Ant2, which is vital for ADP/ATP exchange bet...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-09 | PXD062646 | Pride
Naive t cells Mouse Ant2ko Spleen 
UnknownSingle-cell transcriptomic analyses provide insights into SPP1<sup>+</sup> TAM-mediated immune suppression and CD8<sup>+</sup> T cell dysfunction in lung cancer.
Not available
S-EPMC12480184 | biostudies-literature
TranscriptomicsSpatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (RNA-Seq)
T cell exhaustion is a major impediment to anti-tumor immunity. However, it remains elusive how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional state. Here we show that the biology of tumor-associated macrophages (TAM) and exhausted T cells (Tex) in the TME is...
ORGANISM(S): Mus musculus 
2022-04-26 | GSE201071 | GEO
TranscriptomicsSpatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (scRNA-Seq)
T cell exhaustion is a major impediment to anti-tumor immunity. However, it remains elusive how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional state. Here we show that the biology of tumor-associated macrophages (TAM) and exhausted T cells (Tex) in the TME is...
ORGANISM(S): Mus musculus 
2022-04-26 | GSE201073 | GEO
GenomicsSpatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (ATAC-Seq)
T cell exhaustion is a major impediment to anti-tumor immunity. However, it remains elusive how other immune cells in the tumor microenvironment (TME) contribute to this dysfunctional state. Here we show that the biology of tumor-associated macrophages (TAM) and exhausted T cells (Tex) in the TME is...
ORGANISM(S): Mus musculus 
2022-04-26 | GSE201072 | GEO
UnknownBeyond the hype: A TAM-based analysis of blockchain adoption drivers in construction industry.
Not available
S-EPMC11471537 | biostudies-literature
GenomicsSpatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (ATAC-Seq)
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (ATAC-Seq)
PRJNA828189 | ENA
GenomicsSpatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (RNA-Seq)
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (RNA-Seq)
PRJNA828180 | ENA
GenomicsSpatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (scRNA-Seq)
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells (scRNA-Seq)
PRJNA828188 | ENA
UnknownDifferential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma.
Not available
S-EPMC6548612 | biostudies-literature
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