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ProteomicsAutocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor
Malaria parasite egress from host erythrocytes (RBCs) is regulated by discharge of a parasite serine protease called SUB1 into the parasitophorous vacuole (PV). There, SUB1 activates a PV-resident cysteine protease called SERA6, enabling host RBC rupture through SERA6-mediated degradation of the RBC...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-03-16 | PXD024084 | Pride
Lc-msms Malaria Protease Sub1 Sera6 
ProteomicsPlasmodium PKG interacts with ICM1, a multi-pass membrane protein, in both asexual and sexual stages
In malaria parasites, all cGMP-dependent signalling is mediated through a single cGMP-dependent protein kinase (PKG). A major function of PKG is to control calcium signals essential for the parasite to exit red blood cells or for transmission to the mosquito vector. However, how PKG controls these s...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2021-02-10 | PXD020447 | Pride
Lc-msms Malaria Cell signalling Calcium homeostasis Protein kinase g Orbitrap Plasmodium falciparum 
ProteomicsThe malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion
Red blood cell (RBC) invasion by malaria merozoites involves formation of a parasitophorous vacuole into which the parasite moves. The vacuole membrane then seals and pinches off behind the parasite through an unknown mechanism, enclosing it within the RBC. During invasion, several merozoite surface...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2020-11-27 | PXD021843 | Pride
Malaria Sub2 Protease Orbitrap 
UnknownSafety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.
Not available
S-EPMC7723445 | biostudies-literature
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