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TranscriptomicsHomeodomain dependent gene expression in HOX transformed primary cells
The gene expression profile was determined in primary cells transformed by two different HOX genes (HOXA1 and HOXA9) and by two HOX derivatives where the homeodomain was exchanged.
ORGANISM(S): Mus musculus 
2013-01-31 | E-MEXP-3617 | biostudies-arrayexpress
TranscriptomicsExpression data from the reproductive tracts of WT, Hoxa9,10,11, and Hoxd9,10,11 mutant mice
Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions, and their interspersed shared enhancers. In this report, we describe a novel recombineering strategy that was used to introduce simultaneous frameshif...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-41993 | biostudies-arrayexpress
TranscriptomicsDetermination of HOXA1 and HOXA9 target genes with inducible HOX constructs
Target genes of HOXA1 and HOXA9 were determined with the help of inducible HOX-ER constructs. For this purpose bone marrow was harvested from C57BL/6 mice and c-Kit positive progenitors were enriched by magnetic sorting (MACS technology, Miltenyi, Germany). After retroviral infection by spinoculatio...
ORGANISM(S): Mus musculus 
2012-11-02 | E-MEXP-3648 | biostudies-arrayexpress
GenomicsThe Dynamic Architecture of Hox Gene Clusters
The spatial and temporal control of Hox gene transcription is essential for patterning the vertebrate body axis. Although this process involves changes in histone posttranslational modifications, the existence of particular three-dimensional (3D) architectures remained to be assessed in vivo. Using ...
ORGANISM(S): Mus musculus 
2011-10-12 | E-GEOD-31570 | biostudies-arrayexpress
GenomicsRoles of Cofactors and Chromatin Accessibility in Hox Protein Target Specificity
Regulation of specific target genes by transcription factors is central to gene network control in development. How target specificity is achieved in eukaryotic genomes is poorly understood, as exemplified by the Hox family, which show limited in vitro DNA-binding specificity but clear functional sp...
ORGANISM(S): Drosophila melanogaster 
2015-12-07 | E-GEOD-69796 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NUP98-NSD1 transformed samples reveals NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. INCOMPLETE DATASET
Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers. ...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10071 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila embryos at stages 11 and 12 to identify genes downstream of Hox
Identification of Hox gene downstream genes at embryonic stages 11 and 12

Functional diversification of body parts is dependent on the formation of specialized structures along the various body axes. In animals, region-specific morphogenesis along the anterior-posterior axis is controlled by ...
ORGANISM(S): Drosophila melanogaster 
2008-04-09 | E-MEXP-879 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse rhombomere 4 at E10.5 from knockins of Hoxb1 gene expressing Hox-A1 protein
This study analyzed mRNA profiles in rhombomere 4 of E10.5 mouse knock-in embryos expressing either normal endogenous Hox-B1 protein or the paralogous Hox-A1 protein from the Hoxb1 locus. The Hox-A1 protein was found to be detectably less efficacious than Hox-B1 in promoting neurogenesis in the basa...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5124 | biostudies-arrayexpress
ProteomicsGene- and species-specific Hox mRNA translation by ribosome expansion segments
Ribosomes have been suggested to directly control gene regulation, however regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core ribosome in eukaryotes. ESs are remarkably variable ...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-19 | PXD021678 | Pride
C3h/10t1/2 6plex tmt Hoxa9 4xs1m aptamer Rna structure Lc msms Internal initiation Internal ribosome entry site Affinity purification Mouse fvb embryo e11.5 Ribosome Hox cluster Mrna translation Stem-loop Rna-protein interaction Ribosomal rna 
TranscriptomicsTranscription profiling of mouse adult bone marrow cells reveals candidate genes form expansion and transformation of hematopoietic stem cells by NUP98-HOX Fusion Genes
BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9079 | biostudies-arrayexpress
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