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GenomicsIdentification and Characterization of Hoxa9 Binding Sites in Hematopoietic Cells
The clustered homeobox proteins play crucial roles in development, hematopoiesis and leukemia yet the targets they regulate and their mechanisms of action are poorly understood. Here, we identified the binding sites for Hoxa9 and the Hox cofactor Meis1 on a genome-wide level and profiled their asso...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-33509 | biostudies-arrayexpress
TranscriptomicsHOXA9 transcriptomic analysis in GBM cell lines (U87MG, U251 and primary GBML18) and in immortalized human astrocytes (hTERT/E6/E7)
Assess gene expression patterns upon HOXA9 ectopic expression in U87MG GBM cell line and hTERT/E6/E7 immortalized human astrocytes, and HOXA9 silencing in U251 and GBML18 GBM cell lines. U87MG and hTERT/E6/E7 were retrovirally-infected with an MSCV control vector (MSCV-Control) or with a construct c...
ORGANISM(S): Homo sapiens 
2015-01-30 | E-GEOD-56517 | biostudies-arrayexpress
TranscriptomicsGene expression changes after loss of Hoxa9 in transformed HSCs [HOXA9 RNA-seq]
Characterization of gene expression changes 72 hours after withdrawal of tamoxifen in murine hematopoietic progenitors transformed by Hoxa9-ER/Meis1 using RNAseq. In the presence of tamoxifen (4OHT), Hoxa9-ER localizes to the nucleus of cells allowing for transformation, while withdrawal of 4OHT (cu...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-58359 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Hoxa9-expanded hematopoietic cells expressing distinct TALE genes
Primary murine hematopoietic cells were retrovirally transduced with Hoxa9 cDNA, expanded in vitro before undergoing secondary infection with the cDNA of Meis1, Prep1 and the Prep1-MC mutant. RNA was extracted and transcriptomes were analyzed. Background corrections and normalisations were performe...
ORGANISM(S): Mus musculus 
2011-09-08 | E-MTAB-671 | biostudies-arrayexpress
GenomicsGenome-wide co-occupancy of Hoxa9 and C/EBPα in Hoxa9/Meis1 transformed HSCs [ChIP-seq]
Identification of the genome-wide binding sites of Hoxa9 and C/EBPα in a murine myeloblastic cell line transformed by Hoxa9/Meis1. Over 50% of Hoxa9 binding sites are co-bound by C/EBPα, providing mechanistic insight into the requirement of C/EBPα for Hoxa9-mediated leukemogenesis. Additionally, gen...
ORGANISM(S): Mus musculus 
2014-06-11 | E-GEOD-58361 | biostudies-arrayexpress
TranscriptomicsThe role of Hoxa9 and Meis1 in development of acute myeloid leukemia (mRNA)
OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX proteins, such as HOXA9, to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. To further resolve these mechanisms, we conducted a structure-function analysis of Meis1 and gene expression...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-75272 | biostudies-arrayexpress
ProteomicsNUP98-HOXA9 acute myeloid leukemia
Mass Spectrometry analysis of the interactome of the oncoprotein NUP98-HOXA9
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD001828 | Pride
Fusion protein nup98-hoxa9 Protein-protein interactions Aml 
ModelsTalarmain2022- Model of JAK2/TET2/HOXA9 in myeloproliferative neoplasms
Model describing how HOXA9 may control the evolution of myeloproliferative neoplasms by integrating the orders of JAK2 and TET2 mutation
2023-03-17 | MODEL2212110001 | BioModels
TranscriptomicsG9a-dependent gene expression in mouse AML cells
The methyltransferase G9a was found to play a role in the disease progression of a murine model of AML. Mouse HSPCs were transformed with HoxA9/Meis1 and treated with G9a/GLP inhibitor UNC0638. We used microarrays to detail the global program of gene expression that depends on the methyltransferase ...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-53894 | biostudies-arrayexpress
TranscriptomicsRNAseq of murine primary bone marrow cells transformed by an inducible Hoxa9-ER: time-course
Relative overexpression of HOXA9 is a key feature of aggressive AML (acute myeloid leukemia). Hoxa9 responsive genes were identified by nascent RNA sequencing (4-thio-uridine labeled RNA - sequencing) in samples of primary hematopoietic precursor cells from mice transformed by an tamoxifen inducible...
ORGANISM(S): Mus musculus 
2019-04-13 | E-MTAB-7107 | biostudies-arrayexpress
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