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ProteomicsOptimising a self-assembling peptide hydrogel as a Matrigel alternative for 3-dimensional mammary epithelial cell culture
Three-dimensional (3D) organoid models have been instrumental in understanding molecular mechanisms responsible for many cellular processes and diseases. However, established organic biomaterial scaffolds used for 3D hydrogel cultures, such as Matrigel, are biochemically complex and display signific...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD045193 | Pride
Mammary epithelial cell 3d Laminin Organoid 
ProteomicsPulldown of proteins interacting with SGOL1-AS1 in AML
Epigenetic dysregulation is a common feature of acute myeloid leukemia (AML). Recently it has become clear that long noncoding RNAs (lncRNAs) can play a key role in epigenetic regulation, and consequently also dysregulation. Currently, our understanding of the requirements and roles of lncRNAs in AM...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD034329 | Pride
Long non-coding rna Lncrna Aml Acute myeloid leukemia 
ProteomicsGolgin knockouts alter extracellular matrix secretion
The secretion of extracellular matrix (ECM) proteins is vital to the maintenance of tissue health. One 28 major control point of this process is the Golgi apparatus, whose dysfunction causes numerous 29 connective tissue disorders. Golgi function is tightly linked to its structure, which is maintain...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD061302 | Pride
Secretion Extracellular matrix Golgin 
ProteomicsSILAC labelled tendon fibroblasts
Monitoring protein abundance using Mass Spectrometry within cells is a widely used technique and commonly used. The abundance however is a static measurement with no real information about the dynamics of those proteins and so clearly missing important information. In order to get a better appreciat...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD036794 | Pride
Silac tendon fibroblasts turnover 
ProteomicsBasement membrane turnover and circulating matrix biomarkers in kidney disease
Chronic kidney disease (CKD) is characterised by kidney fibrosis and represents a major public health concern. Alport syndrome, a common monogenic cause of kidney failure caused by genetic variants in the type IV collagen genes COL4A3, COL4A4 or COL4A5, leads to abnormal basement membrane remodellin...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-21 | PXD067091 | Pride
Ecm Kidney Alports Turnover 
ProteomicsKidney matrix dynamics across the life course
Chronic kidney disease (CKD) represents a major public health concern and accounts for massive morbidity, mortality, and financial resource. Advanced age is a major risk factor for progressive CKD and is associated with kidney fibrosis. Dysregulated protein turnover is a hallmark of ageing and leads...
ORGANISM(S): Homo sapiens (Human) 
2026-05-21 | PXD070694 | Pride
Ecm Ageing Turnover Kidney 
UnknownSynovial matrix turnover controls immune cell spatial patterning in inflammation resolution.
Not available
S-SCDT-10_1038-S44320-025-00149-7 | biostudies-other
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