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MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
TranscriptomicsIdentification of markers associated with deregulated hTERT during HPV-medaited transformation
Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit hTERT. Our previo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8288 | biostudies-arrayexpress
GenomicsHuman cervical cells HELP-tagging cytosine methylation data
We pursued the hypothesis that epigenetic regulators of transcription are involved in both the development and the progression of HPV-associated CIN. Using HELP-tagging, we performed the most comprehensive study to date of DNA methylation in HPV-associated cervical neoplasia, testing ~2 million loc...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-76986 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of cervical cancer progression
Affymetrix-U133-plus2.0-based gene expression analysis of laser-captured epithelium from 128 cervical tissue specimens from women enrolled in SUCCEED Cervical cancer (CC) is the second most frequent cancer in women and the third leading cause of cancer death in women worldwide. Our analysis of norma...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-63514 | biostudies-arrayexpress
TranscriptomicsMicroRNA sequencing and Novel HPV miRNA discovery in HPV cell lines and human tissue samples
Human papillomaviruses (HPV) preferentially infect keratinocytes of mucous membranes or skin and cause numerous benign and malignant lesions at different anatomical locations. A number of DNA viruses encode their own miRNAs as well. To date, no studies have been able to validate viral miRNAs in papi...
ORGANISM(S): Homo sapiens 
2013-08-18 | E-GEOD-42380 | biostudies-arrayexpress
TranscriptomicsAltered microRNA expression associated with chromosomal and epigenetic changes contributes to cervical carcinogenesis
Little is known about the alterations in microRNA (miRNA) expression patterns during the consecutive stages of cervical cancer development and their association with chromosomal instability and epigenetic changes. We integrated miRNA expression profiles in normal cervical squamous epithelium, high-g...
ORGANISM(S): Homo sapiens 
2012-06-27 | E-GEOD-30656 | biostudies-arrayexpress
GenomicsHPV E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
PRJEB38189 | ENA
ProteomicsQuantitative proteomic analysis of tumour tissues isolated from early and late stage human cervical cancer patients
Human papillomavirus (HPV) infection related malignancy remains a severe public health problem worldwide, although HPV prophylactic vaccine has been introduced 15 years ago . HPV-associated cancers comprise 29.1% of all 2.2 million infection-related cancers, including nearly 100% of cervical cancers...
ORGANISM(S): Homo sapiens (Human) 
2023-01-26 | PXD029103 | Pride
Itraq8plex Cervical cancer Lc-ms/ms 
TranscriptomicsTranscription profiling of human HPV-positive and -negative head/neck and cervical cancers
Human papillomaviruses (HPVs) are associated with nearly all cervical cancers (CCs), 20-30% of head and neck cancers (HNCs), and other cancers. Because HNCs also arise in HPV-negative patients, this type of cancer provides unique opportunities to define similarities and differences of HPV-positive v...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6791 | biostudies-arrayexpress
TranscriptomicsMicroRNA analysis in HPV-positive and HPV-negative cervical cancer cell lines
Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, includ...
ORGANISM(S): Homo sapiens 
2018-01-16 | E-MTAB-6361 | biostudies-arrayexpress
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