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TranscriptomicsAn integrated global analysis of compartmentalized HRAS signaling
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens 
2019-03-12 | E-MTAB-7672 | biostudies-arrayexpress
ProteomicsAn integrated global analysis of compartmentalized HRAS signaling - Ras IP
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012505 | Pride
Hras hrasv12 hela 
TranscriptomicsTranscription profiling of rat fibroblasts transformed with HRAS and treated with the demethylating agent 5-aza-2-deoxycytidine
Silencing of gene expression by methylation of CpG islands in regulatory elements is frequently observed in cancer. However, an influence of the most common oncogenic signalling pathways onto DNA methylation has not yet been investigated thoroughly. To address this issue, we identified genes suppres...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-4427 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF10A cells reveal changes upon expression of activated versions of MEK1 and HRAS
MCF10A cells were then transfected with MEK1(S217S221), HRAS(G12V), and null control vectors; Cells were lysed 24 hours post-transfection with collection of total RNA and protein Experiment Overall Design: Overexpression of Oncogenic protein was confirmed via Western blot
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12764 | biostudies-arrayexpress
TranscriptomicsGene expression of wild-type and Ppar-beta null primary keratinocytes, with and without infection with an activated Hras retrovirus, with and without the Ppar-beta specific ligand GW0742
Differential gene expression profiles were observed in response to Hras in either wild-type or Ppar-beta null primary keratinocytes and differentail gene edxpression profiles by GW0742 were only found in wild-type keratinocytes. Primary keratinocytes from wild-type and Ppar-beta null mice were eithe...
ORGANISM(S): Mus musculus 
2012-04-11 | E-GEOD-32498 | biostudies-arrayexpress
ProteomicsKinome profiling of HRAS Q61K mutant SMS-CTR rhabdomyosarcoma cell line treated with tipifarnib
Hyperactive RAS signaling drives tumorigenesis in PAX 3/7::FOXO1 fusion-negative rhabdomyosarcoma (FN-RMS). Despite the frequency of these mutations, RAS pathway-directed therapies have been ineffective for RAS-driven RMS. Farnesyltransferase (FTase) inhibitors (FTIs), such as tipifarnib, inhibit HR...
ORGANISM(S): Homo sapiens (Human) 
2026-02-12 | PXD062989 | Pride
Mapk pathway Mek inhibition Ras Farnesyltransferase inhibitor Tumor 
GenomicsCombined inhibition of HRAS and MEK induces tumor regression and restores myogenic differentiation in HRAS-mutant rhabdomyosarcoma
Combined inhibition of HRAS and MEK induces tumor regression and restores myogenic differentiation in HRAS-mutant rhabdomyosarcoma
PRJNA1372080 | ENA
ProteomicsAn integrated global analysis of compartmentalized HRAS signaling - Phosphoproteomics
Modern omics technologies allow us obtaining global information on different types of biological networks. However, integrating these different types of analyzes into a coherent framework for a comprehensive biological interpretation remains challenging. Here, we present a conceptual framework that ...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012506 | Pride
Ras phosphoproteomics minetei localisation 
GenomicsHelleday HRAS Project
This experiment is looking at the mutational signatures generated by engineered HRAS mutations by using whole genome sequence generated on massively parallel next generation sequencers.
EGAS00001000332 | EGA
TranscriptomicsNormal mouse skin lacking Hras
Oncogenic activating mutations in Ras genes are among the most common drivers of human disease. Treating mouse skin with the chemical carcinogen DMBA induces a characteristic mutation in Hras at codon 61. To understand how skin responds to a constitutive lack of Hras, we generated a cohort of Hras k...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-60769 | biostudies-arrayexpress
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