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ProteomicsGenotype-dependent N-glycosylation and newly discovered O-glycosylation affecting HRG plasmin cleavage
Histidine-rich glycoprotein (HRG) is an abundant plasma glycoprotein with three reported N-glycosylation sites, which integrates many biological processes such as antiangiogenic activity, immune complex clearance and pathogen clearance. Importantly, the protein is known to have five genetic variants...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044353 | Pride
Histidine-rich glycoprotein (hrg) O-glycosylation Glycoproteomics Plasmin cleavage N-glycosylation 
TranscriptomicsExpression data from isolated peritoneal macrophages treated with Histidine-rich glycoprotein
Histidine-rich glycoprotein (HRG) is a 75 kDa heparin-binding plasma protein which has been implicated in regulation of tumor angiogenesis and growth. To exert some of its biological functions, HRG acts on macrophages.This study was performed to assess changes in gene expression in peritoneal macrop...
ORGANISM(S): Mus musculus 
2011-12-06 | E-GEOD-34164 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of C. elegans reveals heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins
Hemes are essential but potentially cytotoxic cofactors that participate in critical and diverse biological processes. Although the pathway and intermediates for heme biosynthesis have been well defined, the intracellular networks which mediate heme trafficking remain unknown. Caenorhabditis e...
ORGANISM(S): Caenorhabditis elegans 
2008-10-18 | E-GEOD-8696 | biostudies-arrayexpress
ProteomicsHDX-MS of Human Histidine Rich Glycoprotein (HRG)
Histidine rich glycoprotein (HRG) is a multi-domain plasma glycoprotein, which is implicated in numerous biological processes including immune regulation, angiogenesis, coagulation and fibrinolysis. Despite a diverse role of biological functions, structural investigations into HRG have yielded only ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-11-06 | PXD065786 | Pride
Hrg Hdx-ms 
TranscriptomicsTranscription profiling of rat ureteric buds treated with either heregulin, pleiotrophin or conditioned medium from metanephric mesenchymal cell culture
Genes ontologically classified as proliferative and developmental were down-regulated by HRG, whereas those involved in transport were up-regulated. For example, the mRNA for the GDNF receptors, GFRa1 and ret9 were down-regulated while the mRNA for collecting duct transporters, such as urea transpor...
ORGANISM(S): Rattus norvegicus 
2007-10-10 | E-GEOD-3394 | biostudies-arrayexpress
ProteomicsPolymorphic Histidine-rich Glycoprotein LC-MS/MS
Histidine-rich glycoprotein (HRG) HRG is a liver-produced protein circulating in human plasma serum at high concentrations of around 125 ug/mL. HRG belongs to the family of type-3 cystatins and has been implicated in a plethora of biological processes, albeit its precise function is still not well u...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040914 | Pride
Serum proteomics  histidine-rich glycoprotein (hrg)  plasma proteomics  protein biomarker  proteogenomics  1000-genome 
TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 breast cancer cells MCF-7 two hours post incubation with heregulin (HRG)) vs. controls to detect HRG regulated genes
Heregulin beta-1 (HRG) is an extracellular ligand that activates mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathways through ErbB receptors. MAPK and Akt have been shown to phosphorylate the estrogen receptor (ER) at Ser-118 and Ser-167, respect...
ORGANISM(S): Homo sapiens 
2008-04-08 | E-GEOD-8471 | biostudies-arrayexpress
TranscriptomicsMCF7 HRG stimulation
Heregulin beta-1 (HRG) is an extracellular ligand that activates mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathways through ErbB receptors. MAPK and Akt have been shown to phosphorylate the estrogen receptor (ER) at Ser-118 and Ser-167, respect...
ORGANISM(S): Homo sapiens 
2008-02-08 | GSE8471 | GEO
ProteomicsBafilomycin A1 is a promising therapeutic agent against T. spiralis infection by inhibiting the heme-transporting ATP6V0C/HRG-1 complex
These data represent the mass spectrometry results from the interaction proteomics analysis of HRG-1 in Trichinella spiralis.
ORGANISM(S): Trichinella Spiralis 
2026-01-28 | PXD073737 |
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