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ProteomicsProteomics effects of HSP60 deficiency in HEK cells, using an inducible transgenic HSP60 ATPase deficient mutant.
To investigate the immediate effect of HSP60 dysfunction on mitochondrial functions, we induced the expression of a dominant-negative ATPase-deficient HSP60 mutant (HSP60-D423A) in HEK293 cells using tetracycline . Incorporation of HSP60-D423A subunits into HSP60 heptamer rings leads to dysfunction ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048918 | Pride
Hsp60 deficiency Mitochondria Chaperone Differential protein expression 
GenomicsModelling HSP60 deficiency using an inducible transgenic HSP60 ATPase deficient mutant
Modelling HSP60 deficiency using an inducible transgenic HSP60 ATPase deficient mutant
PRJNA1070667 | ENA
ProteomicsProteomic mapping of fibroblasts from patients with HSP60 deficiency
Deficiency of the mitochondrial chaperone HSP60 has detrimental effects on the mitochondrial functions, and can in patient’s lead to hypomyelination disorder. The present study investigates the proteome in cultivated skin fibroblasts originating from two patients with HSP60 genetic variants and hypo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD048923 | Pride
Hsp60 Lc-ms Mitochondria Fibroblast 
TranscriptomicsCytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels by regulating NF-κB-dependent gene expression
Pro-inflammatory response of VSMCs is triggered by endothelial damage and a causative step for thrombosis and neointimal thickening in the arterial vessels. Therefore, we investigate a role of cytosolic Hsp60 as a novel pro-inflammatory mediator in VSMCs. Hsp60 was detected in the cytosol of VSMCs....
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-65354 | biostudies-arrayexpress
ProteomicsThe proteomics effects of HSP60 chaperone deficiency in zebrafish larvae
To understand the effects of Hsp60 deficiency in developing vertebrates, we generated CRISPR/Cas9-mediated hspd1 knockout zebrafish lines by targeting exon 2 to induce a frameshift mutation. We selected an allele with a 56 base pair deletion inducing a frameshift mutation leading to loss of protein ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-09-27 | PXD048920 | Pride
Larvae. lc-ms Hsp60 Chaperone Zebrafish 
TranscriptomicsModelling HSP60 deficiency using an inducible transgenic HSP60 ATPase deficient mutant
To investigate the immediate effect of HSP60 dysfunction on mitochondrial functions, we induced the expression of a dominant-negative ATPase-deficient HSP60 mutant (HSP60-D423A) in HEK293 cells using tetracycline . Incorporation of HSP60-D423A subunits into HSP60 heptamer rings leads to dysfunction ...
ORGANISM(S): Homo sapiens 
2024-09-27 | GSE254495 | GEO
GenomicsThe effects of HSP60 chaperone deficiency on zebrafish larvae
The effects of HSP60 chaperone deficiency on zebrafish larvae
PRJNA1068542 | ENA
TranscriptomicsThe effects of HSP60 chaperone deficiency on zebrafish larvae
To understand the effects of Hsp60 deficiency in developing vertebrates, we generated CRISPR/Cas9-mediated hspd1 knockout zebrafish lines by targeting exon 2 to induce a frameshift mutation. We selected an allele with a 56 base pair deletion inducing a frameshift mutation leading to loss of protein ...
ORGANISM(S): Danio rerio 
2024-09-27 | GSE254091 | GEO
UnknownHSP60 chaperone deficiency disrupts the mitochondrial matrix proteome and dysregulates cholesterol synthesis.
Not available
S-EPMC11388177 | biostudies-literature
GenomicsImmune Tolerance to HSP60 Attenuates Neurodegeneration in Glaucoma
Immune Tolerance to HSP60 Attenuates Neurodegeneration in Glaucoma
PRJNA1119479 | ENA
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